The effect of age on the in vitro metabolism of androgen by guinea pig testis

Charles A. Snipes; W. Gary Becker; C. J. Migeon

doi:10.1016/0039-128X(65)90099-1

The effect of age on the in vitro metabolism of androgen by guinea pig testis

Charles A. Snipes, W. Gary Becker, C. J. Migeon

Research output: Contribution to journal › Article › peer-review

12 Scopus citations

Abstract

Progesterone-4-C¹⁴ was incubated with minces of testes from Guinea pigs of different ages. Progesterone-C¹⁴ disappearance and 17α-hydroxyprogesterone-C¹⁴ appearance did not change consistently with age. However, more androstenedione-C¹⁴ and less testosterone-C¹⁴ appeared in tissue from younger animals. It is concluded that androstenedione is reduced less readily in younger animals.

Original language	English (US)
Pages (from-to)	771-776
Number of pages	6
Journal	Steroids
Volume	6
Issue number	6
DOIs	https://doi.org/10.1016/0039-128X(65)90099-1
State	Published - Dec 1965
Externally published	Yes

ASJC Scopus subject areas

Biochemistry
Molecular Biology
Endocrinology
Pharmacology
Clinical Biochemistry
Organic Chemistry

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10.1016/0039-128X(65)90099-1

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@article{2248393a106545258be9615402e631ae,

title = "The effect of age on the in vitro metabolism of androgen by guinea pig testis",

abstract = "Progesterone-4-C14 was incubated with minces of testes from Guinea pigs of different ages. Progesterone-C14 disappearance and 17α-hydroxyprogesterone-C14 appearance did not change consistently with age. However, more androstenedione-C14 and less testosterone-C14 appeared in tissue from younger animals. It is concluded that androstenedione is reduced less readily in younger animals.",

author = "Snipes, {Charles A.} and Becker, {W. Gary} and Migeon, {C. J.}",

note = "Funding Information: Supported in part by NIH grants AM-00180-13 and Tl-AM 5219-05. W. G. B. was supported by medical student research funds from the NIH. C. J. M, has a Research Career Award from the NIH. We are indebted to Dr. Ferenc Gyorkey for making some of the microscopic slides.",

year = "1965",

month = dec,

doi = "10.1016/0039-128X(65)90099-1",

language = "English (US)",

volume = "6",

pages = "771--776",

journal = "Steroids",

issn = "0039-128X",

publisher = "Elsevier Inc.",

number = "6",

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T1 - The effect of age on the in vitro metabolism of androgen by guinea pig testis

AU - Snipes, Charles A.

AU - Becker, W. Gary

AU - Migeon, C. J.

N1 - Funding Information: Supported in part by NIH grants AM-00180-13 and Tl-AM 5219-05. W. G. B. was supported by medical student research funds from the NIH. C. J. M, has a Research Career Award from the NIH. We are indebted to Dr. Ferenc Gyorkey for making some of the microscopic slides.

PY - 1965/12

Y1 - 1965/12

N2 - Progesterone-4-C14 was incubated with minces of testes from Guinea pigs of different ages. Progesterone-C14 disappearance and 17α-hydroxyprogesterone-C14 appearance did not change consistently with age. However, more androstenedione-C14 and less testosterone-C14 appeared in tissue from younger animals. It is concluded that androstenedione is reduced less readily in younger animals.

AB - Progesterone-4-C14 was incubated with minces of testes from Guinea pigs of different ages. Progesterone-C14 disappearance and 17α-hydroxyprogesterone-C14 appearance did not change consistently with age. However, more androstenedione-C14 and less testosterone-C14 appeared in tissue from younger animals. It is concluded that androstenedione is reduced less readily in younger animals.

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SN - 0039-128X

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SP - 771

EP - 776

JO - Steroids

JF - Steroids

IS - 6

ER -

The effect of age on the in vitro metabolism of androgen by guinea pig testis

Abstract

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