The effect of age on odor-stimulated functional MR imaging

David Mark Yousem, Joseph A. Maldjian, Thomas Hummel, David C. Alsop, Rena J. Geckle, Michael A Kraut, Richard L. Doty

Research output: Contribution to journalArticle

Abstract

BACKGROUND AND PURPOSE: The effects of age, sex, and handedness on olfaction have not been adequately addressed with odor-stimulated functional MR imaging studies. We sought to determine the effect of age on functional MR imaging experiments performed with odor stimulation. METHODS: Five right- handed subjects with a mean age of 73 years and five right-handed subjects with a mean age of 24 years underwent gradient-echo echo-planar functional MR imaging using binasal olfactory stimulation. Imaging parameters included 3000/30 (TR/TE) and a 5-mm section thickness in a 6-minute sequence with 30 seconds of pulsed odorants alternating with 30 seconds of room air. The data were normalized to a standard atlas, and individual and group statistical parametric maps (SPMs) were generated for each task. The SPMs were thresholded for a P <.01, and the volumes of activation and distribution of cluster maxima were compared for the two groups. RESULTS: Analysis of the group SPMs revealed activated voxels in the frontal lobes, perisylvian regions, and cingulate gyri, with greater volume in the younger group than in the older group. The right inferior frontal, right perisylvian, and right and left cingulum had the largest number of voxels activated. The most common sites of activation on individual maps in both groups were the right inferior frontal regions and the right and left superior frontal and perisylvian zones. CONCLUSION: Given similar olfactory task paradigms, younger subjects showed a greater number of activated voxels than did older subjects. One must be cognizant of this effect when designing studies of odor-stimulated functional MR imaging.

Original languageEnglish (US)
Pages (from-to)600-608
Number of pages9
JournalAmerican Journal of Neuroradiology
Volume20
Issue number4
StatePublished - 1999

Fingerprint

Functional Laterality
Smell
Atlases
Gyrus Cinguli
Frontal Lobe
Air
Odorants
TE 5

ASJC Scopus subject areas

  • Clinical Neurology
  • Radiology Nuclear Medicine and imaging
  • Radiological and Ultrasound Technology

Cite this

Yousem, D. M., Maldjian, J. A., Hummel, T., Alsop, D. C., Geckle, R. J., Kraut, M. A., & Doty, R. L. (1999). The effect of age on odor-stimulated functional MR imaging. American Journal of Neuroradiology, 20(4), 600-608.

The effect of age on odor-stimulated functional MR imaging. / Yousem, David Mark; Maldjian, Joseph A.; Hummel, Thomas; Alsop, David C.; Geckle, Rena J.; Kraut, Michael A; Doty, Richard L.

In: American Journal of Neuroradiology, Vol. 20, No. 4, 1999, p. 600-608.

Research output: Contribution to journalArticle

Yousem, DM, Maldjian, JA, Hummel, T, Alsop, DC, Geckle, RJ, Kraut, MA & Doty, RL 1999, 'The effect of age on odor-stimulated functional MR imaging', American Journal of Neuroradiology, vol. 20, no. 4, pp. 600-608.
Yousem DM, Maldjian JA, Hummel T, Alsop DC, Geckle RJ, Kraut MA et al. The effect of age on odor-stimulated functional MR imaging. American Journal of Neuroradiology. 1999;20(4):600-608.
Yousem, David Mark ; Maldjian, Joseph A. ; Hummel, Thomas ; Alsop, David C. ; Geckle, Rena J. ; Kraut, Michael A ; Doty, Richard L. / The effect of age on odor-stimulated functional MR imaging. In: American Journal of Neuroradiology. 1999 ; Vol. 20, No. 4. pp. 600-608.
@article{12e2914169964138a932e61e5cc82de8,
title = "The effect of age on odor-stimulated functional MR imaging",
abstract = "BACKGROUND AND PURPOSE: The effects of age, sex, and handedness on olfaction have not been adequately addressed with odor-stimulated functional MR imaging studies. We sought to determine the effect of age on functional MR imaging experiments performed with odor stimulation. METHODS: Five right- handed subjects with a mean age of 73 years and five right-handed subjects with a mean age of 24 years underwent gradient-echo echo-planar functional MR imaging using binasal olfactory stimulation. Imaging parameters included 3000/30 (TR/TE) and a 5-mm section thickness in a 6-minute sequence with 30 seconds of pulsed odorants alternating with 30 seconds of room air. The data were normalized to a standard atlas, and individual and group statistical parametric maps (SPMs) were generated for each task. The SPMs were thresholded for a P <.01, and the volumes of activation and distribution of cluster maxima were compared for the two groups. RESULTS: Analysis of the group SPMs revealed activated voxels in the frontal lobes, perisylvian regions, and cingulate gyri, with greater volume in the younger group than in the older group. The right inferior frontal, right perisylvian, and right and left cingulum had the largest number of voxels activated. The most common sites of activation on individual maps in both groups were the right inferior frontal regions and the right and left superior frontal and perisylvian zones. CONCLUSION: Given similar olfactory task paradigms, younger subjects showed a greater number of activated voxels than did older subjects. One must be cognizant of this effect when designing studies of odor-stimulated functional MR imaging.",
author = "Yousem, {David Mark} and Maldjian, {Joseph A.} and Thomas Hummel and Alsop, {David C.} and Geckle, {Rena J.} and Kraut, {Michael A} and Doty, {Richard L.}",
year = "1999",
language = "English (US)",
volume = "20",
pages = "600--608",
journal = "American Journal of Neuroradiology",
issn = "0195-6108",
publisher = "American Society of Neuroradiology",
number = "4",

}

TY - JOUR

T1 - The effect of age on odor-stimulated functional MR imaging

AU - Yousem, David Mark

AU - Maldjian, Joseph A.

AU - Hummel, Thomas

AU - Alsop, David C.

AU - Geckle, Rena J.

AU - Kraut, Michael A

AU - Doty, Richard L.

PY - 1999

Y1 - 1999

N2 - BACKGROUND AND PURPOSE: The effects of age, sex, and handedness on olfaction have not been adequately addressed with odor-stimulated functional MR imaging studies. We sought to determine the effect of age on functional MR imaging experiments performed with odor stimulation. METHODS: Five right- handed subjects with a mean age of 73 years and five right-handed subjects with a mean age of 24 years underwent gradient-echo echo-planar functional MR imaging using binasal olfactory stimulation. Imaging parameters included 3000/30 (TR/TE) and a 5-mm section thickness in a 6-minute sequence with 30 seconds of pulsed odorants alternating with 30 seconds of room air. The data were normalized to a standard atlas, and individual and group statistical parametric maps (SPMs) were generated for each task. The SPMs were thresholded for a P <.01, and the volumes of activation and distribution of cluster maxima were compared for the two groups. RESULTS: Analysis of the group SPMs revealed activated voxels in the frontal lobes, perisylvian regions, and cingulate gyri, with greater volume in the younger group than in the older group. The right inferior frontal, right perisylvian, and right and left cingulum had the largest number of voxels activated. The most common sites of activation on individual maps in both groups were the right inferior frontal regions and the right and left superior frontal and perisylvian zones. CONCLUSION: Given similar olfactory task paradigms, younger subjects showed a greater number of activated voxels than did older subjects. One must be cognizant of this effect when designing studies of odor-stimulated functional MR imaging.

AB - BACKGROUND AND PURPOSE: The effects of age, sex, and handedness on olfaction have not been adequately addressed with odor-stimulated functional MR imaging studies. We sought to determine the effect of age on functional MR imaging experiments performed with odor stimulation. METHODS: Five right- handed subjects with a mean age of 73 years and five right-handed subjects with a mean age of 24 years underwent gradient-echo echo-planar functional MR imaging using binasal olfactory stimulation. Imaging parameters included 3000/30 (TR/TE) and a 5-mm section thickness in a 6-minute sequence with 30 seconds of pulsed odorants alternating with 30 seconds of room air. The data were normalized to a standard atlas, and individual and group statistical parametric maps (SPMs) were generated for each task. The SPMs were thresholded for a P <.01, and the volumes of activation and distribution of cluster maxima were compared for the two groups. RESULTS: Analysis of the group SPMs revealed activated voxels in the frontal lobes, perisylvian regions, and cingulate gyri, with greater volume in the younger group than in the older group. The right inferior frontal, right perisylvian, and right and left cingulum had the largest number of voxels activated. The most common sites of activation on individual maps in both groups were the right inferior frontal regions and the right and left superior frontal and perisylvian zones. CONCLUSION: Given similar olfactory task paradigms, younger subjects showed a greater number of activated voxels than did older subjects. One must be cognizant of this effect when designing studies of odor-stimulated functional MR imaging.

UR - http://www.scopus.com/inward/record.url?scp=0033361001&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0033361001&partnerID=8YFLogxK

M3 - Article

C2 - 10319969

AN - SCOPUS:0033361001

VL - 20

SP - 600

EP - 608

JO - American Journal of Neuroradiology

JF - American Journal of Neuroradiology

SN - 0195-6108

IS - 4

ER -