The effect of acth administration on plasma testosterone, dihydrotestosterone and serum lh concentrations in normal men

Inese Z. Beitins, Francis Bayard, Avinoam Kowarski, Claude J. Migeon

Research output: Contribution to journalArticlepeer-review

Abstract

Plasma cortisol (F), testosterone (T), dihydrotestosterone (DHT) and serum luteinizing hormone (LH) concentrations were measured in 8 normal young men at 8 AM on two control days. Exogenous adrenocorticotrophin (ACTH) 20 U.S.P. units per m2 of body surface area every 12 or 6 hours was administered intramuscularly for 4 days. Twenty-four hours after starting ACTH administration, the plasma T and DHT concentrations were significantly lower than those of the control days on a paired t test. No significant change in serum LH concentration could be demonstrated. Similar results were observed after 48, 72 and 96 hours of ACTH stimulation.

Original languageEnglish (US)
Pages (from-to)553-563
Number of pages11
JournalSteroids
Volume21
Issue number4
DOIs
StatePublished - Apr 1973

Keywords

  • 17β-hydroxy-5α-androstan-3-one
  • 4-androstene-3,17-dione
  • Androstenedione (Δ)
  • Dihydrotestosterone (DHT)

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Endocrinology
  • Pharmacology
  • Clinical Biochemistry
  • Organic Chemistry

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