The effect of a histamine synthesis inhibitor on the immediate nasal allergic reaction

U. Pipkorn, G. Granerus, D. Proud, A. Kagey-Sobotka, Philip S. Norman, L. M. Lichtenstein, R. M. Naclerio

Research output: Contribution to journalArticle

Abstract

We studied the effect of α-fluoromethyl histidine, an irreversible histamine synthesis inhibitor, on the immediate nasal reaction to antigen challenge in a double-blind, placebo controlled, randomized, parallel study using 13 subjects. The patients received either active drug 100 mg twice daily or placebo, for 3 weeks. A nasal allergen challenge was performed before and after at weekly intervals. Symptoms at challenge were assessed and the levels of histamine, TAME-esterase activity and kinins were measured in nasal lavages before and after antigen challenge. Skin tests were also performed at weekly intervals. In addition, the urinary excretion of the main histamine metabolite, telemethylimidazole acetic acid, was measured before and after 3 weeks of treatment. The active treatment induced 60% reduction in histamine levels in the lavage fluids before and after antigen challenge, as well as a reduction in the histamine levels in the lavage fluids before and after antigen challenge, as well as a reduction in the main urinary histamine metabolite. However, no reduction was found in nasal symptoms obtained after antigen challenge. The levels of kinins and TAME-esterase activity were not significantly reduced.

Original languageEnglish (US)
Pages (from-to)496-501
Number of pages6
JournalAllergy: European Journal of Allergy and Clinical Immunology
Volume42
Issue number7
StatePublished - 1987
Externally publishedYes

Fingerprint

Nose
Histamine
Hypersensitivity
Antigens
Kinins
Therapeutic Irrigation
Placebos
Nasal Lavage
Skin Tests
Histidine
Acetic Acid
Allergens
Therapeutics
Pharmaceutical Preparations

ASJC Scopus subject areas

  • Immunology

Cite this

Pipkorn, U., Granerus, G., Proud, D., Kagey-Sobotka, A., Norman, P. S., Lichtenstein, L. M., & Naclerio, R. M. (1987). The effect of a histamine synthesis inhibitor on the immediate nasal allergic reaction. Allergy: European Journal of Allergy and Clinical Immunology, 42(7), 496-501.

The effect of a histamine synthesis inhibitor on the immediate nasal allergic reaction. / Pipkorn, U.; Granerus, G.; Proud, D.; Kagey-Sobotka, A.; Norman, Philip S.; Lichtenstein, L. M.; Naclerio, R. M.

In: Allergy: European Journal of Allergy and Clinical Immunology, Vol. 42, No. 7, 1987, p. 496-501.

Research output: Contribution to journalArticle

Pipkorn, U, Granerus, G, Proud, D, Kagey-Sobotka, A, Norman, PS, Lichtenstein, LM & Naclerio, RM 1987, 'The effect of a histamine synthesis inhibitor on the immediate nasal allergic reaction', Allergy: European Journal of Allergy and Clinical Immunology, vol. 42, no. 7, pp. 496-501.
Pipkorn, U. ; Granerus, G. ; Proud, D. ; Kagey-Sobotka, A. ; Norman, Philip S. ; Lichtenstein, L. M. ; Naclerio, R. M. / The effect of a histamine synthesis inhibitor on the immediate nasal allergic reaction. In: Allergy: European Journal of Allergy and Clinical Immunology. 1987 ; Vol. 42, No. 7. pp. 496-501.
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