The early treatment for retinopathy of prematurity study

Structural findings at age 2 years

William V. Good, Robert J. Hardy, Velma Dobson, Earl A. Palmer, Dale L. Phelps, Michelle Quintos, Betty Tung, Ashima Madan, M. Bethany Ball, Patricia N. Hartsell, Dottie Inguillo, Michael Gaynon, Deborah Alcorn, Donna Ornitz, Judith Gancasz, David Durand, Terri Slagle, Gordon Smith, Michael Shapiro, Yesenia Garcia & 159 others Maria Genio, Jeffrey N. Bloom, Lawrence Kaufman, Wico Waikwan Lai, Marilyn Miller, Daniel Neely, Elizabeth A. Hynes, James Lemons, David Plager, Naval Sondhi, Derek Sprunger, Paul J. Rychwalski, Greg K. Whittington, Peggy H. Fishman, Robert A. Gordon, Deborah S. Neff, Douglas B. Babel, James G. Diamond, William L. Gill, Scott M. Steidl, Kelly A. Hutcheson, Kevin Powdrill, Eric Jones, Mark W. Preslan, Michael X Repka, Jennifer A. Shepard, Pamela Donahue, Susan W Aucott, Mary Louise Z Collins, Maureen Gilmore, James Handa, Cynthia H. Cole, Deborah VanderVeen, Terri Mansfield, Brenda MacKinnon, Anthony Fraioli, O'ine McCabe, Robert Peterson, David Hunter, Sarah MacKinnon, Rhiannon Johnson, Mariette Tyedmers, John Baker, Krist Cumming, Pat Manatrey, Antonio Capone, Edward O'Malley, Rajesh Rao, John Roarty, Michael Trese, George Williams, Stephen P. Christiansen, Sally Cook, Ann Holleschau, C. Gail Summers, Bradley V. Davitt, Linda Breuer, Oscar Cruz, William Keenan, Greg Mantych, Gregg Lueder, Sharon Freedman, David Wallace, Lori Hutchins Parkman, Sarah Jones, Laura Enyedi, James D. Reynolds, Kristine Ziemann, George P. Albert, Steven Awner, Rita Ryan, Pamela Ann Weber, Marc Horowitz, Cherylene Behrendt, Natalie Dweck, Richard Koty, Edmund LaGamma, John Flynn, Thomas C. Lee, Osode Coki, Michael Chiang, Steven Kane, Richard Polin, Cassandra Horihan, Jane Phillips, Gary Markowitz, Walter Merriam, Leon Paul Noel, Donald Tingley, Matthew Gearinger, Gary L. Rogers, Don Bremer, Rae Fellows, Sharon Klamfoth, Brian Arthur, Cybil Bean Cassady, Leandro Cordero, Richard Golden, Richard Hertle, Richard McClead, Mary Lou McGregor, R. Michael Siatkowski, Lisa Ogilbee, Cheryl Harris, Reagan H. Bradford, Robert E. Leonard, Mary Anne McCaffree, David T. Wheeler, Nancy Dolphin, Ann Stout, Brian Nichols, David Epley, Graham E. Quinn, Jamie G. Koh, Soraya Abbasi, Jane C. Edmond, Brian J. Forbes, Albert M. Maguire, Monte D. Mills, Terri L. Young, Stephanie Davidson, Kenneth Cheng, Judith Jones, Robert Bergren, Beverly Brozanski, Bernard Doft, Louis Lobes, Karl Olsen, Richard A. Saunders, Linda Stevens, M. Millicent Peterseim, Edward Wilson, Dilip Purohit, David K. Coats, Michele L. Parker, Maria Castanes, Evelyn A. Paysee, Kimberly G. Yen, Joseph Garcia-Prats, W. A J Van Heuven, Yolanda Trigo, James C. MacDonald, Robert Hoffman, Susan Bracken, Paul Bernstein, Jerald King, Michael Teske, Maryann Redford, Richard L. Mowery, Donald F. Everett, Claudia Pedroza, Gordon Tsai, John Connett, Edward F. Donovan, Argye Hillis, Jonathan M. Holmes, Joseph M. Miller, Carol R. Taylor, Charles Barr

Research output: Contribution to journalArticle

Abstract

Objective: To determine whether earlier treatment of high-risk, prethreshold retinopathy of prematurity (ROP) improves retinal structural outcome at 2 years of age. Methods: Infants with bilateral high-risk prethreshold ROP had one eye randomly assigned to treatment with peripheral retinal ablation. The fellow eye was managed conventionally, and either treated at threshold ROP or observed if threshold was never reached. In patients with asymmetrical disease, the high-risk, prethreshold eye was randomised to earlier treatment or to conventional management. At 2 years of age, children were examined comprehensively by certified ophthalmologists to determine structural outcomes for their eyes. For the purposes of this study, an unfavourable structural outcome was defined as (1) a posterior retinal fold involving the macula, (2) a retinal detachment involving the macula or (3) retrolental tissue or "mass" obscuring the view of the posterior pole. Results of the 2-year examination were compared with those from the 9 months examination. Results: Data were available on 339 of 374 (90.6%) surviving children. Unfavourable structural outcomes were reduced from 15.4% in conventionally managed eyes to 9.1% in earlier-treated eyes (p = 0.002) at 2 years of age. Ophthalmic side effects (excluding retinal structure) from the ROP or its treatment were similar in the earlier-treated eyes and the conventionally managed eyes. Conclusion: The benefit of earlier treatment of high-risk prethreshold ROP on retinal structure endures to 2 years of age, and is not counterbalanced by any known side effect caused by earlier intervention. Earlier treatment improves the chance for long-term favourable retinal structural outcome in eyes with high-risk prethreshold ROP. Long-term follow-up is planned to determine structural and functional outcomes at 6 years of age.

Original languageEnglish (US)
Pages (from-to)1378-1382
Number of pages5
JournalBritish Journal of Ophthalmology
Volume90
Issue number11
DOIs
StatePublished - Nov 2006
Externally publishedYes

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Retinopathy of Prematurity
Therapeutics
Retinal Detachment

ASJC Scopus subject areas

  • Ophthalmology

Cite this

Good, W. V., Hardy, R. J., Dobson, V., Palmer, E. A., Phelps, D. L., Quintos, M., ... Barr, C. (2006). The early treatment for retinopathy of prematurity study: Structural findings at age 2 years. British Journal of Ophthalmology, 90(11), 1378-1382. https://doi.org/10.1136/bjo.2006.098582

The early treatment for retinopathy of prematurity study : Structural findings at age 2 years. / Good, William V.; Hardy, Robert J.; Dobson, Velma; Palmer, Earl A.; Phelps, Dale L.; Quintos, Michelle; Tung, Betty; Madan, Ashima; Ball, M. Bethany; Hartsell, Patricia N.; Inguillo, Dottie; Gaynon, Michael; Alcorn, Deborah; Ornitz, Donna; Gancasz, Judith; Durand, David; Slagle, Terri; Smith, Gordon; Shapiro, Michael; Garcia, Yesenia; Genio, Maria; Bloom, Jeffrey N.; Kaufman, Lawrence; Lai, Wico Waikwan; Miller, Marilyn; Neely, Daniel; Hynes, Elizabeth A.; Lemons, James; Plager, David; Sondhi, Naval; Sprunger, Derek; Rychwalski, Paul J.; Whittington, Greg K.; Fishman, Peggy H.; Gordon, Robert A.; Neff, Deborah S.; Babel, Douglas B.; Diamond, James G.; Gill, William L.; Steidl, Scott M.; Hutcheson, Kelly A.; Powdrill, Kevin; Jones, Eric; Preslan, Mark W.; Repka, Michael X; Shepard, Jennifer A.; Donahue, Pamela; Aucott, Susan W; Collins, Mary Louise Z; Gilmore, Maureen; Handa, James; Cole, Cynthia H.; VanderVeen, Deborah; Mansfield, Terri; MacKinnon, Brenda; Fraioli, Anthony; McCabe, O'ine; Peterson, Robert; Hunter, David; MacKinnon, Sarah; Johnson, Rhiannon; Tyedmers, Mariette; Baker, John; Cumming, Krist; Manatrey, Pat; Capone, Antonio; O'Malley, Edward; Rao, Rajesh; Roarty, John; Trese, Michael; Williams, George; Christiansen, Stephen P.; Cook, Sally; Holleschau, Ann; Summers, C. Gail; Davitt, Bradley V.; Breuer, Linda; Cruz, Oscar; Keenan, William; Mantych, Greg; Lueder, Gregg; Freedman, Sharon; Wallace, David; Parkman, Lori Hutchins; Jones, Sarah; Enyedi, Laura; Reynolds, James D.; Ziemann, Kristine; Albert, George P.; Awner, Steven; Ryan, Rita; Weber, Pamela Ann; Horowitz, Marc; Behrendt, Cherylene; Dweck, Natalie; Koty, Richard; LaGamma, Edmund; Flynn, John; Lee, Thomas C.; Coki, Osode; Chiang, Michael; Kane, Steven; Polin, Richard; Horihan, Cassandra; Phillips, Jane; Markowitz, Gary; Merriam, Walter; Noel, Leon Paul; Tingley, Donald; Gearinger, Matthew; Rogers, Gary L.; Bremer, Don; Fellows, Rae; Klamfoth, Sharon; Arthur, Brian; Cassady, Cybil Bean; Cordero, Leandro; Golden, Richard; Hertle, Richard; McClead, Richard; McGregor, Mary Lou; Siatkowski, R. Michael; Ogilbee, Lisa; Harris, Cheryl; Bradford, Reagan H.; Leonard, Robert E.; McCaffree, Mary Anne; Wheeler, David T.; Dolphin, Nancy; Stout, Ann; Nichols, Brian; Epley, David; Quinn, Graham E.; Koh, Jamie G.; Abbasi, Soraya; Edmond, Jane C.; Forbes, Brian J.; Maguire, Albert M.; Mills, Monte D.; Young, Terri L.; Davidson, Stephanie; Cheng, Kenneth; Jones, Judith; Bergren, Robert; Brozanski, Beverly; Doft, Bernard; Lobes, Louis; Olsen, Karl; Saunders, Richard A.; Stevens, Linda; Peterseim, M. Millicent; Wilson, Edward; Purohit, Dilip; Coats, David K.; Parker, Michele L.; Castanes, Maria; Paysee, Evelyn A.; Yen, Kimberly G.; Garcia-Prats, Joseph; Van Heuven, W. A J; Trigo, Yolanda; MacDonald, James C.; Hoffman, Robert; Bracken, Susan; Bernstein, Paul; King, Jerald; Teske, Michael; Redford, Maryann; Mowery, Richard L.; Everett, Donald F.; Pedroza, Claudia; Tsai, Gordon; Connett, John; Donovan, Edward F.; Hillis, Argye; Holmes, Jonathan M.; Miller, Joseph M.; Taylor, Carol R.; Barr, Charles.

In: British Journal of Ophthalmology, Vol. 90, No. 11, 11.2006, p. 1378-1382.

Research output: Contribution to journalArticle

Good, WV, Hardy, RJ, Dobson, V, Palmer, EA, Phelps, DL, Quintos, M, Tung, B, Madan, A, Ball, MB, Hartsell, PN, Inguillo, D, Gaynon, M, Alcorn, D, Ornitz, D, Gancasz, J, Durand, D, Slagle, T, Smith, G, Shapiro, M, Garcia, Y, Genio, M, Bloom, JN, Kaufman, L, Lai, WW, Miller, M, Neely, D, Hynes, EA, Lemons, J, Plager, D, Sondhi, N, Sprunger, D, Rychwalski, PJ, Whittington, GK, Fishman, PH, Gordon, RA, Neff, DS, Babel, DB, Diamond, JG, Gill, WL, Steidl, SM, Hutcheson, KA, Powdrill, K, Jones, E, Preslan, MW, Repka, MX, Shepard, JA, Donahue, P, Aucott, SW, Collins, MLZ, Gilmore, M, Handa, J, Cole, CH, VanderVeen, D, Mansfield, T, MacKinnon, B, Fraioli, A, McCabe, O, Peterson, R, Hunter, D, MacKinnon, S, Johnson, R, Tyedmers, M, Baker, J, Cumming, K, Manatrey, P, Capone, A, O'Malley, E, Rao, R, Roarty, J, Trese, M, Williams, G, Christiansen, SP, Cook, S, Holleschau, A, Summers, CG, Davitt, BV, Breuer, L, Cruz, O, Keenan, W, Mantych, G, Lueder, G, Freedman, S, Wallace, D, Parkman, LH, Jones, S, Enyedi, L, Reynolds, JD, Ziemann, K, Albert, GP, Awner, S, Ryan, R, Weber, PA, Horowitz, M, Behrendt, C, Dweck, N, Koty, R, LaGamma, E, Flynn, J, Lee, TC, Coki, O, Chiang, M, Kane, S, Polin, R, Horihan, C, Phillips, J, Markowitz, G, Merriam, W, Noel, LP, Tingley, D, Gearinger, M, Rogers, GL, Bremer, D, Fellows, R, Klamfoth, S, Arthur, B, Cassady, CB, Cordero, L, Golden, R, Hertle, R, McClead, R, McGregor, ML, Siatkowski, RM, Ogilbee, L, Harris, C, Bradford, RH, Leonard, RE, McCaffree, MA, Wheeler, DT, Dolphin, N, Stout, A, Nichols, B, Epley, D, Quinn, GE, Koh, JG, Abbasi, S, Edmond, JC, Forbes, BJ, Maguire, AM, Mills, MD, Young, TL, Davidson, S, Cheng, K, Jones, J, Bergren, R, Brozanski, B, Doft, B, Lobes, L, Olsen, K, Saunders, RA, Stevens, L, Peterseim, MM, Wilson, E, Purohit, D, Coats, DK, Parker, ML, Castanes, M, Paysee, EA, Yen, KG, Garcia-Prats, J, Van Heuven, WAJ, Trigo, Y, MacDonald, JC, Hoffman, R, Bracken, S, Bernstein, P, King, J, Teske, M, Redford, M, Mowery, RL, Everett, DF, Pedroza, C, Tsai, G, Connett, J, Donovan, EF, Hillis, A, Holmes, JM, Miller, JM, Taylor, CR & Barr, C 2006, 'The early treatment for retinopathy of prematurity study: Structural findings at age 2 years', British Journal of Ophthalmology, vol. 90, no. 11, pp. 1378-1382. https://doi.org/10.1136/bjo.2006.098582
Good, William V. ; Hardy, Robert J. ; Dobson, Velma ; Palmer, Earl A. ; Phelps, Dale L. ; Quintos, Michelle ; Tung, Betty ; Madan, Ashima ; Ball, M. Bethany ; Hartsell, Patricia N. ; Inguillo, Dottie ; Gaynon, Michael ; Alcorn, Deborah ; Ornitz, Donna ; Gancasz, Judith ; Durand, David ; Slagle, Terri ; Smith, Gordon ; Shapiro, Michael ; Garcia, Yesenia ; Genio, Maria ; Bloom, Jeffrey N. ; Kaufman, Lawrence ; Lai, Wico Waikwan ; Miller, Marilyn ; Neely, Daniel ; Hynes, Elizabeth A. ; Lemons, James ; Plager, David ; Sondhi, Naval ; Sprunger, Derek ; Rychwalski, Paul J. ; Whittington, Greg K. ; Fishman, Peggy H. ; Gordon, Robert A. ; Neff, Deborah S. ; Babel, Douglas B. ; Diamond, James G. ; Gill, William L. ; Steidl, Scott M. ; Hutcheson, Kelly A. ; Powdrill, Kevin ; Jones, Eric ; Preslan, Mark W. ; Repka, Michael X ; Shepard, Jennifer A. ; Donahue, Pamela ; Aucott, Susan W ; Collins, Mary Louise Z ; Gilmore, Maureen ; Handa, James ; Cole, Cynthia H. ; VanderVeen, Deborah ; Mansfield, Terri ; MacKinnon, Brenda ; Fraioli, Anthony ; McCabe, O'ine ; Peterson, Robert ; Hunter, David ; MacKinnon, Sarah ; Johnson, Rhiannon ; Tyedmers, Mariette ; Baker, John ; Cumming, Krist ; Manatrey, Pat ; Capone, Antonio ; O'Malley, Edward ; Rao, Rajesh ; Roarty, John ; Trese, Michael ; Williams, George ; Christiansen, Stephen P. ; Cook, Sally ; Holleschau, Ann ; Summers, C. Gail ; Davitt, Bradley V. ; Breuer, Linda ; Cruz, Oscar ; Keenan, William ; Mantych, Greg ; Lueder, Gregg ; Freedman, Sharon ; Wallace, David ; Parkman, Lori Hutchins ; Jones, Sarah ; Enyedi, Laura ; Reynolds, James D. ; Ziemann, Kristine ; Albert, George P. ; Awner, Steven ; Ryan, Rita ; Weber, Pamela Ann ; Horowitz, Marc ; Behrendt, Cherylene ; Dweck, Natalie ; Koty, Richard ; LaGamma, Edmund ; Flynn, John ; Lee, Thomas C. ; Coki, Osode ; Chiang, Michael ; Kane, Steven ; Polin, Richard ; Horihan, Cassandra ; Phillips, Jane ; Markowitz, Gary ; Merriam, Walter ; Noel, Leon Paul ; Tingley, Donald ; Gearinger, Matthew ; Rogers, Gary L. ; Bremer, Don ; Fellows, Rae ; Klamfoth, Sharon ; Arthur, Brian ; Cassady, Cybil Bean ; Cordero, Leandro ; Golden, Richard ; Hertle, Richard ; McClead, Richard ; McGregor, Mary Lou ; Siatkowski, R. Michael ; Ogilbee, Lisa ; Harris, Cheryl ; Bradford, Reagan H. ; Leonard, Robert E. ; McCaffree, Mary Anne ; Wheeler, David T. ; Dolphin, Nancy ; Stout, Ann ; Nichols, Brian ; Epley, David ; Quinn, Graham E. ; Koh, Jamie G. ; Abbasi, Soraya ; Edmond, Jane C. ; Forbes, Brian J. ; Maguire, Albert M. ; Mills, Monte D. ; Young, Terri L. ; Davidson, Stephanie ; Cheng, Kenneth ; Jones, Judith ; Bergren, Robert ; Brozanski, Beverly ; Doft, Bernard ; Lobes, Louis ; Olsen, Karl ; Saunders, Richard A. ; Stevens, Linda ; Peterseim, M. Millicent ; Wilson, Edward ; Purohit, Dilip ; Coats, David K. ; Parker, Michele L. ; Castanes, Maria ; Paysee, Evelyn A. ; Yen, Kimberly G. ; Garcia-Prats, Joseph ; Van Heuven, W. A J ; Trigo, Yolanda ; MacDonald, James C. ; Hoffman, Robert ; Bracken, Susan ; Bernstein, Paul ; King, Jerald ; Teske, Michael ; Redford, Maryann ; Mowery, Richard L. ; Everett, Donald F. ; Pedroza, Claudia ; Tsai, Gordon ; Connett, John ; Donovan, Edward F. ; Hillis, Argye ; Holmes, Jonathan M. ; Miller, Joseph M. ; Taylor, Carol R. ; Barr, Charles. / The early treatment for retinopathy of prematurity study : Structural findings at age 2 years. In: British Journal of Ophthalmology. 2006 ; Vol. 90, No. 11. pp. 1378-1382.
@article{b2f676795d6f409f8fe136a428960f5c,
title = "The early treatment for retinopathy of prematurity study: Structural findings at age 2 years",
abstract = "Objective: To determine whether earlier treatment of high-risk, prethreshold retinopathy of prematurity (ROP) improves retinal structural outcome at 2 years of age. Methods: Infants with bilateral high-risk prethreshold ROP had one eye randomly assigned to treatment with peripheral retinal ablation. The fellow eye was managed conventionally, and either treated at threshold ROP or observed if threshold was never reached. In patients with asymmetrical disease, the high-risk, prethreshold eye was randomised to earlier treatment or to conventional management. At 2 years of age, children were examined comprehensively by certified ophthalmologists to determine structural outcomes for their eyes. For the purposes of this study, an unfavourable structural outcome was defined as (1) a posterior retinal fold involving the macula, (2) a retinal detachment involving the macula or (3) retrolental tissue or {"}mass{"} obscuring the view of the posterior pole. Results of the 2-year examination were compared with those from the 9 months examination. Results: Data were available on 339 of 374 (90.6{\%}) surviving children. Unfavourable structural outcomes were reduced from 15.4{\%} in conventionally managed eyes to 9.1{\%} in earlier-treated eyes (p = 0.002) at 2 years of age. Ophthalmic side effects (excluding retinal structure) from the ROP or its treatment were similar in the earlier-treated eyes and the conventionally managed eyes. Conclusion: The benefit of earlier treatment of high-risk prethreshold ROP on retinal structure endures to 2 years of age, and is not counterbalanced by any known side effect caused by earlier intervention. Earlier treatment improves the chance for long-term favourable retinal structural outcome in eyes with high-risk prethreshold ROP. Long-term follow-up is planned to determine structural and functional outcomes at 6 years of age.",
author = "Good, {William V.} and Hardy, {Robert J.} and Velma Dobson and Palmer, {Earl A.} and Phelps, {Dale L.} and Michelle Quintos and Betty Tung and Ashima Madan and Ball, {M. Bethany} and Hartsell, {Patricia N.} and Dottie Inguillo and Michael Gaynon and Deborah Alcorn and Donna Ornitz and Judith Gancasz and David Durand and Terri Slagle and Gordon Smith and Michael Shapiro and Yesenia Garcia and Maria Genio and Bloom, {Jeffrey N.} and Lawrence Kaufman and Lai, {Wico Waikwan} and Marilyn Miller and Daniel Neely and Hynes, {Elizabeth A.} and James Lemons and David Plager and Naval Sondhi and Derek Sprunger and Rychwalski, {Paul J.} and Whittington, {Greg K.} and Fishman, {Peggy H.} and Gordon, {Robert A.} and Neff, {Deborah S.} and Babel, {Douglas B.} and Diamond, {James G.} and Gill, {William L.} and Steidl, {Scott M.} and Hutcheson, {Kelly A.} and Kevin Powdrill and Eric Jones and Preslan, {Mark W.} and Repka, {Michael X} and Shepard, {Jennifer A.} and Pamela Donahue and Aucott, {Susan W} and Collins, {Mary Louise Z} and Maureen Gilmore and James Handa and Cole, {Cynthia H.} and Deborah VanderVeen and Terri Mansfield and Brenda MacKinnon and Anthony Fraioli and O'ine McCabe and Robert Peterson and David Hunter and Sarah MacKinnon and Rhiannon Johnson and Mariette Tyedmers and John Baker and Krist Cumming and Pat Manatrey and Antonio Capone and Edward O'Malley and Rajesh Rao and John Roarty and Michael Trese and George Williams and Christiansen, {Stephen P.} and Sally Cook and Ann Holleschau and Summers, {C. Gail} and Davitt, {Bradley V.} and Linda Breuer and Oscar Cruz and William Keenan and Greg Mantych and Gregg Lueder and Sharon Freedman and David Wallace and Parkman, {Lori Hutchins} and Sarah Jones and Laura Enyedi and Reynolds, {James D.} and Kristine Ziemann and Albert, {George P.} and Steven Awner and Rita Ryan and Weber, {Pamela Ann} and Marc Horowitz and Cherylene Behrendt and Natalie Dweck and Richard Koty and Edmund LaGamma and John Flynn and Lee, {Thomas C.} and Osode Coki and Michael Chiang and Steven Kane and Richard Polin and Cassandra Horihan and Jane Phillips and Gary Markowitz and Walter Merriam and Noel, {Leon Paul} and Donald Tingley and Matthew Gearinger and Rogers, {Gary L.} and Don Bremer and Rae Fellows and Sharon Klamfoth and Brian Arthur and Cassady, {Cybil Bean} and Leandro Cordero and Richard Golden and Richard Hertle and Richard McClead and McGregor, {Mary Lou} and Siatkowski, {R. Michael} and Lisa Ogilbee and Cheryl Harris and Bradford, {Reagan H.} and Leonard, {Robert E.} and McCaffree, {Mary Anne} and Wheeler, {David T.} and Nancy Dolphin and Ann Stout and Brian Nichols and David Epley and Quinn, {Graham E.} and Koh, {Jamie G.} and Soraya Abbasi and Edmond, {Jane C.} and Forbes, {Brian J.} and Maguire, {Albert M.} and Mills, {Monte D.} and Young, {Terri L.} and Stephanie Davidson and Kenneth Cheng and Judith Jones and Robert Bergren and Beverly Brozanski and Bernard Doft and Louis Lobes and Karl Olsen and Saunders, {Richard A.} and Linda Stevens and Peterseim, {M. Millicent} and Edward Wilson and Dilip Purohit and Coats, {David K.} and Parker, {Michele L.} and Maria Castanes and Paysee, {Evelyn A.} and Yen, {Kimberly G.} and Joseph Garcia-Prats and {Van Heuven}, {W. A J} and Yolanda Trigo and MacDonald, {James C.} and Robert Hoffman and Susan Bracken and Paul Bernstein and Jerald King and Michael Teske and Maryann Redford and Mowery, {Richard L.} and Everett, {Donald F.} and Claudia Pedroza and Gordon Tsai and John Connett and Donovan, {Edward F.} and Argye Hillis and Holmes, {Jonathan M.} and Miller, {Joseph M.} and Taylor, {Carol R.} and Charles Barr",
year = "2006",
month = "11",
doi = "10.1136/bjo.2006.098582",
language = "English (US)",
volume = "90",
pages = "1378--1382",
journal = "British Journal of Ophthalmology",
issn = "0007-1161",
publisher = "BMJ Publishing Group",
number = "11",

}

TY - JOUR

T1 - The early treatment for retinopathy of prematurity study

T2 - Structural findings at age 2 years

AU - Good, William V.

AU - Hardy, Robert J.

AU - Dobson, Velma

AU - Palmer, Earl A.

AU - Phelps, Dale L.

AU - Quintos, Michelle

AU - Tung, Betty

AU - Madan, Ashima

AU - Ball, M. Bethany

AU - Hartsell, Patricia N.

AU - Inguillo, Dottie

AU - Gaynon, Michael

AU - Alcorn, Deborah

AU - Ornitz, Donna

AU - Gancasz, Judith

AU - Durand, David

AU - Slagle, Terri

AU - Smith, Gordon

AU - Shapiro, Michael

AU - Garcia, Yesenia

AU - Genio, Maria

AU - Bloom, Jeffrey N.

AU - Kaufman, Lawrence

AU - Lai, Wico Waikwan

AU - Miller, Marilyn

AU - Neely, Daniel

AU - Hynes, Elizabeth A.

AU - Lemons, James

AU - Plager, David

AU - Sondhi, Naval

AU - Sprunger, Derek

AU - Rychwalski, Paul J.

AU - Whittington, Greg K.

AU - Fishman, Peggy H.

AU - Gordon, Robert A.

AU - Neff, Deborah S.

AU - Babel, Douglas B.

AU - Diamond, James G.

AU - Gill, William L.

AU - Steidl, Scott M.

AU - Hutcheson, Kelly A.

AU - Powdrill, Kevin

AU - Jones, Eric

AU - Preslan, Mark W.

AU - Repka, Michael X

AU - Shepard, Jennifer A.

AU - Donahue, Pamela

AU - Aucott, Susan W

AU - Collins, Mary Louise Z

AU - Gilmore, Maureen

AU - Handa, James

AU - Cole, Cynthia H.

AU - VanderVeen, Deborah

AU - Mansfield, Terri

AU - MacKinnon, Brenda

AU - Fraioli, Anthony

AU - McCabe, O'ine

AU - Peterson, Robert

AU - Hunter, David

AU - MacKinnon, Sarah

AU - Johnson, Rhiannon

AU - Tyedmers, Mariette

AU - Baker, John

AU - Cumming, Krist

AU - Manatrey, Pat

AU - Capone, Antonio

AU - O'Malley, Edward

AU - Rao, Rajesh

AU - Roarty, John

AU - Trese, Michael

AU - Williams, George

AU - Christiansen, Stephen P.

AU - Cook, Sally

AU - Holleschau, Ann

AU - Summers, C. Gail

AU - Davitt, Bradley V.

AU - Breuer, Linda

AU - Cruz, Oscar

AU - Keenan, William

AU - Mantych, Greg

AU - Lueder, Gregg

AU - Freedman, Sharon

AU - Wallace, David

AU - Parkman, Lori Hutchins

AU - Jones, Sarah

AU - Enyedi, Laura

AU - Reynolds, James D.

AU - Ziemann, Kristine

AU - Albert, George P.

AU - Awner, Steven

AU - Ryan, Rita

AU - Weber, Pamela Ann

AU - Horowitz, Marc

AU - Behrendt, Cherylene

AU - Dweck, Natalie

AU - Koty, Richard

AU - LaGamma, Edmund

AU - Flynn, John

AU - Lee, Thomas C.

AU - Coki, Osode

AU - Chiang, Michael

AU - Kane, Steven

AU - Polin, Richard

AU - Horihan, Cassandra

AU - Phillips, Jane

AU - Markowitz, Gary

AU - Merriam, Walter

AU - Noel, Leon Paul

AU - Tingley, Donald

AU - Gearinger, Matthew

AU - Rogers, Gary L.

AU - Bremer, Don

AU - Fellows, Rae

AU - Klamfoth, Sharon

AU - Arthur, Brian

AU - Cassady, Cybil Bean

AU - Cordero, Leandro

AU - Golden, Richard

AU - Hertle, Richard

AU - McClead, Richard

AU - McGregor, Mary Lou

AU - Siatkowski, R. Michael

AU - Ogilbee, Lisa

AU - Harris, Cheryl

AU - Bradford, Reagan H.

AU - Leonard, Robert E.

AU - McCaffree, Mary Anne

AU - Wheeler, David T.

AU - Dolphin, Nancy

AU - Stout, Ann

AU - Nichols, Brian

AU - Epley, David

AU - Quinn, Graham E.

AU - Koh, Jamie G.

AU - Abbasi, Soraya

AU - Edmond, Jane C.

AU - Forbes, Brian J.

AU - Maguire, Albert M.

AU - Mills, Monte D.

AU - Young, Terri L.

AU - Davidson, Stephanie

AU - Cheng, Kenneth

AU - Jones, Judith

AU - Bergren, Robert

AU - Brozanski, Beverly

AU - Doft, Bernard

AU - Lobes, Louis

AU - Olsen, Karl

AU - Saunders, Richard A.

AU - Stevens, Linda

AU - Peterseim, M. Millicent

AU - Wilson, Edward

AU - Purohit, Dilip

AU - Coats, David K.

AU - Parker, Michele L.

AU - Castanes, Maria

AU - Paysee, Evelyn A.

AU - Yen, Kimberly G.

AU - Garcia-Prats, Joseph

AU - Van Heuven, W. A J

AU - Trigo, Yolanda

AU - MacDonald, James C.

AU - Hoffman, Robert

AU - Bracken, Susan

AU - Bernstein, Paul

AU - King, Jerald

AU - Teske, Michael

AU - Redford, Maryann

AU - Mowery, Richard L.

AU - Everett, Donald F.

AU - Pedroza, Claudia

AU - Tsai, Gordon

AU - Connett, John

AU - Donovan, Edward F.

AU - Hillis, Argye

AU - Holmes, Jonathan M.

AU - Miller, Joseph M.

AU - Taylor, Carol R.

AU - Barr, Charles

PY - 2006/11

Y1 - 2006/11

N2 - Objective: To determine whether earlier treatment of high-risk, prethreshold retinopathy of prematurity (ROP) improves retinal structural outcome at 2 years of age. Methods: Infants with bilateral high-risk prethreshold ROP had one eye randomly assigned to treatment with peripheral retinal ablation. The fellow eye was managed conventionally, and either treated at threshold ROP or observed if threshold was never reached. In patients with asymmetrical disease, the high-risk, prethreshold eye was randomised to earlier treatment or to conventional management. At 2 years of age, children were examined comprehensively by certified ophthalmologists to determine structural outcomes for their eyes. For the purposes of this study, an unfavourable structural outcome was defined as (1) a posterior retinal fold involving the macula, (2) a retinal detachment involving the macula or (3) retrolental tissue or "mass" obscuring the view of the posterior pole. Results of the 2-year examination were compared with those from the 9 months examination. Results: Data were available on 339 of 374 (90.6%) surviving children. Unfavourable structural outcomes were reduced from 15.4% in conventionally managed eyes to 9.1% in earlier-treated eyes (p = 0.002) at 2 years of age. Ophthalmic side effects (excluding retinal structure) from the ROP or its treatment were similar in the earlier-treated eyes and the conventionally managed eyes. Conclusion: The benefit of earlier treatment of high-risk prethreshold ROP on retinal structure endures to 2 years of age, and is not counterbalanced by any known side effect caused by earlier intervention. Earlier treatment improves the chance for long-term favourable retinal structural outcome in eyes with high-risk prethreshold ROP. Long-term follow-up is planned to determine structural and functional outcomes at 6 years of age.

AB - Objective: To determine whether earlier treatment of high-risk, prethreshold retinopathy of prematurity (ROP) improves retinal structural outcome at 2 years of age. Methods: Infants with bilateral high-risk prethreshold ROP had one eye randomly assigned to treatment with peripheral retinal ablation. The fellow eye was managed conventionally, and either treated at threshold ROP or observed if threshold was never reached. In patients with asymmetrical disease, the high-risk, prethreshold eye was randomised to earlier treatment or to conventional management. At 2 years of age, children were examined comprehensively by certified ophthalmologists to determine structural outcomes for their eyes. For the purposes of this study, an unfavourable structural outcome was defined as (1) a posterior retinal fold involving the macula, (2) a retinal detachment involving the macula or (3) retrolental tissue or "mass" obscuring the view of the posterior pole. Results of the 2-year examination were compared with those from the 9 months examination. Results: Data were available on 339 of 374 (90.6%) surviving children. Unfavourable structural outcomes were reduced from 15.4% in conventionally managed eyes to 9.1% in earlier-treated eyes (p = 0.002) at 2 years of age. Ophthalmic side effects (excluding retinal structure) from the ROP or its treatment were similar in the earlier-treated eyes and the conventionally managed eyes. Conclusion: The benefit of earlier treatment of high-risk prethreshold ROP on retinal structure endures to 2 years of age, and is not counterbalanced by any known side effect caused by earlier intervention. Earlier treatment improves the chance for long-term favourable retinal structural outcome in eyes with high-risk prethreshold ROP. Long-term follow-up is planned to determine structural and functional outcomes at 6 years of age.

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U2 - 10.1136/bjo.2006.098582

DO - 10.1136/bjo.2006.098582

M3 - Article

VL - 90

SP - 1378

EP - 1382

JO - British Journal of Ophthalmology

JF - British Journal of Ophthalmology

SN - 0007-1161

IS - 11

ER -