The early detection research network surface-enhanced laser desorption and ionization prostate cancer detection study: A study in biomarker validation in genitourinary oncology

William E. Grizzle, O. John Semmes, Joseph Basler, Elzbieta Izbicka, Ziding Feng, Jacob Kagan, Bao Ling Adam, Dean Troyer, Sudhir Srivastava, Mark Thornquist, Zhen Zhang, Ian M. Thompson

Research output: Contribution to journalArticle

Abstract

Prostate-specific antigen (PSA) screening has led to a dramatic increase in prostate cancer detection with a concurrent stage migration. Although the test has revolutionized prostate cancer detection by identifying disease that is potentially curable in the majority of men, only 25% of men receiving test results of PSA >4 ng/ml will have prostate cancer and many men receiving a normal PSA will have disease, including high-grade disease. There is a need for improved biomarkers for detecting prostate cancer. One such method of cancer detection is surface-enhanced laser desorption and ionization (SELDI). The Early Detection Research Network (EDRN) validation study for SELDI for prostate cancer is described. In a three-stage study, the portability and reproducibility of the technique will be determined; the predictive algorithm will be refined in a multi-institutional case-control population; followed by ultimate validation in the context of a prospective trial with complete disease ascertainment. The unique aspect of the EDRN SELDI validation study is the novel use of two groups of cancer cases: those cases with higher-risk disease (Gleason ≥ 7) and those cases with lower-risk disease (Gleason ≤ 6). This study will allow the first evaluation of a predictive algorithm that includes prognosis in disease screening. The EDRN SELDI prostate cancer biomarker validation study is a rigorous evaluation of a new detection method for prostate cancer. The methodologies used for this evaluation will prove useful for guiding future biomarker studies in this challenging disease.

Original languageEnglish (US)
Pages (from-to)337-343
Number of pages7
JournalUrologic Oncology: Seminars and Original Investigations
Volume22
Issue number4
DOIs
StatePublished - Jul 1 2004

Keywords

  • Biomarkers
  • Cancer detection
  • Prostate cancer
  • Proteomics
  • SELDI

ASJC Scopus subject areas

  • Oncology
  • Urology

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