The early detection of pancreatic cancer: What will it take to diagnose and treat curable pancreatic neoplasia?

Anne Marie Lennon; Christopher L. Wolfgang; Marcia Irene Canto; Alison P. Klein; Joseph M. Herman; Michael Goggins; Elliot K. Fishman; Ihab Kamel; Matthew J. Weiss; Luis A. Diaz; Nickolas Papadopoulos; Kenneth W. Kinzler; Bert Vogelstein; Ralph H. Hruban

doi:10.1158/0008-5472.CAN-14-0734

The early detection of pancreatic cancer: What will it take to diagnose and treat curable pancreatic neoplasia?

Anne Marie Lennon, Christopher L. Wolfgang, Marcia Irene Canto, Alison P. Klein, Joseph M. Herman, Michael Goggins, Elliot K. Fishman, Ihab Kamel, Matthew J. Weiss, Luis A. Diaz, Nickolas Papadopoulos, Kenneth W. Kinzler, Bert Vogelstein, Ralph H. Hruban

Research output: Contribution to journal › Review article › peer-review

143 Scopus citations

Abstract

Pancreatic cancer is the deadliest of all solid malignancies. Early detection offers the best hope for a cure, but characteristics of this disease, such as the lack of early clinical symptoms, make the early detection difficult. Recent genetic mapping of the molecular evolution of pancreatic cancer suggests that a large window of opportunity exists for the early detection of pancreatic neoplasia, and developments in cancer genetics offer new, potentially highly specific approaches for screening of curable pancreatic neoplasia. We review the challenges of screening for early pancreatic neoplasia, as well as opportunities presented by incorporating molecular genetics into these efforts. Cancer Res; 74(13); 3381-9.

Original language	English (US)
Pages (from-to)	3381-3389
Number of pages	9
Journal	Cancer Research
Volume	74
Issue number	13
DOIs	https://doi.org/10.1158/0008-5472.CAN-14-0734
State	Published - Jul 1 2014

ASJC Scopus subject areas

Oncology
Cancer Research

Access to Document

10.1158/0008-5472.CAN-14-0734

Cite this

Lennon, A. M., Wolfgang, C. L., Canto, M. I., Klein, A. P., Herman, J. M., Goggins, M., Fishman, E. K., Kamel, I., Weiss, M. J., Diaz, L. A., Papadopoulos, N., Kinzler, K. W., Vogelstein, B., & Hruban, R. H. (2014). The early detection of pancreatic cancer: What will it take to diagnose and treat curable pancreatic neoplasia? Cancer Research, 74(13), 3381-3389. https://doi.org/10.1158/0008-5472.CAN-14-0734

Lennon, AM, Wolfgang, CL, Canto, MI , Klein, AP, Herman, JM, Goggins, M , Fishman, EK, Kamel, I, Weiss, MJ, Diaz, LA, Papadopoulos, N , Kinzler, KW , Vogelstein, B & Hruban, RH 2014, 'The early detection of pancreatic cancer: What will it take to diagnose and treat curable pancreatic neoplasia?', Cancer Research, vol. 74, no. 13, pp. 3381-3389. https://doi.org/10.1158/0008-5472.CAN-14-0734

@article{3ee24af81b2746edaac03f3ba42b5c9a,

title = "The early detection of pancreatic cancer: What will it take to diagnose and treat curable pancreatic neoplasia?",

abstract = "Pancreatic cancer is the deadliest of all solid malignancies. Early detection offers the best hope for a cure, but characteristics of this disease, such as the lack of early clinical symptoms, make the early detection difficult. Recent genetic mapping of the molecular evolution of pancreatic cancer suggests that a large window of opportunity exists for the early detection of pancreatic neoplasia, and developments in cancer genetics offer new, potentially highly specific approaches for screening of curable pancreatic neoplasia. We review the challenges of screening for early pancreatic neoplasia, as well as opportunities presented by incorporating molecular genetics into these efforts. Cancer Res; 74(13); 3381-9.",

author = "Lennon, {Anne Marie} and Wolfgang, {Christopher L.} and Canto, {Marcia Irene} and Klein, {Alison P.} and Herman, {Joseph M.} and Michael Goggins and Fishman, {Elliot K.} and Ihab Kamel and Weiss, {Matthew J.} and Diaz, {Luis A.} and Nickolas Papadopoulos and Kinzler, {Kenneth W.} and Bert Vogelstein and Hruban, {Ralph H.}",

year = "2014",

month = jul,

day = "1",

doi = "10.1158/0008-5472.CAN-14-0734",

language = "English (US)",

volume = "74",

pages = "3381--3389",

journal = "Cancer Research",

issn = "0008-5472",

publisher = "American Association for Cancer Research Inc.",

number = "13",

}

TY - JOUR

T1 - The early detection of pancreatic cancer

T2 - What will it take to diagnose and treat curable pancreatic neoplasia?

AU - Lennon, Anne Marie

AU - Wolfgang, Christopher L.

AU - Canto, Marcia Irene

AU - Klein, Alison P.

AU - Herman, Joseph M.

AU - Goggins, Michael

AU - Fishman, Elliot K.

AU - Kamel, Ihab

AU - Weiss, Matthew J.

AU - Diaz, Luis A.

AU - Papadopoulos, Nickolas

AU - Kinzler, Kenneth W.

AU - Vogelstein, Bert

AU - Hruban, Ralph H.

PY - 2014/7/1

Y1 - 2014/7/1

N2 - Pancreatic cancer is the deadliest of all solid malignancies. Early detection offers the best hope for a cure, but characteristics of this disease, such as the lack of early clinical symptoms, make the early detection difficult. Recent genetic mapping of the molecular evolution of pancreatic cancer suggests that a large window of opportunity exists for the early detection of pancreatic neoplasia, and developments in cancer genetics offer new, potentially highly specific approaches for screening of curable pancreatic neoplasia. We review the challenges of screening for early pancreatic neoplasia, as well as opportunities presented by incorporating molecular genetics into these efforts. Cancer Res; 74(13); 3381-9.

AB - Pancreatic cancer is the deadliest of all solid malignancies. Early detection offers the best hope for a cure, but characteristics of this disease, such as the lack of early clinical symptoms, make the early detection difficult. Recent genetic mapping of the molecular evolution of pancreatic cancer suggests that a large window of opportunity exists for the early detection of pancreatic neoplasia, and developments in cancer genetics offer new, potentially highly specific approaches for screening of curable pancreatic neoplasia. We review the challenges of screening for early pancreatic neoplasia, as well as opportunities presented by incorporating molecular genetics into these efforts. Cancer Res; 74(13); 3381-9.

UR - http://www.scopus.com/inward/record.url?scp=84903955049&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84903955049&partnerID=8YFLogxK

U2 - 10.1158/0008-5472.CAN-14-0734

DO - 10.1158/0008-5472.CAN-14-0734

M3 - Review article

C2 - 24924775

AN - SCOPUS:84903955049

SN - 0008-5472

VL - 74

SP - 3381

EP - 3389

JO - Cancer Research

JF - Cancer Research

IS - 13

ER -

The early detection of pancreatic cancer: What will it take to diagnose and treat curable pancreatic neoplasia?

Abstract

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this