The E-cadherin cell-cell adhesion pathway in urologic malignancies

R. A. Morton, C. M. Ewing, J. J. Watkins, W. B. Isaacs

Research output: Contribution to journalArticlepeer-review

Abstract

Alterations in the E-cadherin-mediated cell-cell adhesion pathway are commonly observed in urologic malignancies. This issue has been addressed most thoroughly in prostate cancer. Whereas both cadherin and catenin dysfunction have been seen in human prostate cancers, only down-regulation of E-cadherin has been shown for bladder cancer and renal-cell carcinoma. Although studies in bladder cancer and renal-cell carcinoma are less mature than studies in prostate cancer, they support the hypothesis that immunostaining for E-cadherin may be of significance for both diagnostic and prognostic purposes. Finally, the E-cadherin-mediated cell-cell adhesion pathway may represent a novel chemotherapeutic target for bladder cancer, prostate cancer, and renal-cell carcinoma. Obviously, more work lies ahead to translate these important observations from the bench to the bedside.

Original languageEnglish (US)
Pages (from-to)364-368
Number of pages5
JournalWorld journal of urology
Volume13
Issue number6
DOIs
StatePublished - Dec 1 1995

ASJC Scopus subject areas

  • Urology

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