The dynamic metabolism of hyaluronan regulates the cytosolic concentration of UDP-GlcNAc

Vincent C. Hascall, Aimin Wang, Markku Tammi, Sanna Oikari, Raija Tammi, Alberto Passi, Davide Vigetti, Richard W. Hanson, Gerald Warren Hart

Research output: Contribution to journalArticle

Abstract

Hyaluronan, a macromolecular glycosaminoglycan, is normally synthesized by hyaluronan synthases at the plasma membrane using cytosolic UDP-GlcUA and UDP-GlcNAc substrates and extruding the elongating chain into the extracellular space. The cellular metabolism (synthesis and catabolism) of hyaluronan is dynamic. UDP-GlcNAc is also the substrate for O-GlcNAc transferase, which is central to the control of many cytosolic pathways. This Perspective outlines recent data for regulation of hyaluronan synthesis and catabolism that support a model that hyaluronan metabolism can be a rheostat for controlling an acceptable normal range of cytosolic UDP-GlcNAc concentrations in order to maintain normal cell functions.

Original languageEnglish (US)
Pages (from-to)14-17
Number of pages4
JournalMatrix Biology
Volume35
DOIs
StatePublished - 2014

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Uridine Diphosphate
Hyaluronic Acid
Extracellular Space
Glycosaminoglycans
Reference Values
Cell Membrane

Keywords

  • Hyaluronan
  • Hyaluronan synthases
  • O-GlcNAc transferase
  • UDP-GlcNAc

ASJC Scopus subject areas

  • Molecular Biology
  • Medicine(all)

Cite this

Hascall, V. C., Wang, A., Tammi, M., Oikari, S., Tammi, R., Passi, A., ... Hart, G. W. (2014). The dynamic metabolism of hyaluronan regulates the cytosolic concentration of UDP-GlcNAc. Matrix Biology, 35, 14-17. https://doi.org/10.1016/j.matbio.2014.01.014

The dynamic metabolism of hyaluronan regulates the cytosolic concentration of UDP-GlcNAc. / Hascall, Vincent C.; Wang, Aimin; Tammi, Markku; Oikari, Sanna; Tammi, Raija; Passi, Alberto; Vigetti, Davide; Hanson, Richard W.; Hart, Gerald Warren.

In: Matrix Biology, Vol. 35, 2014, p. 14-17.

Research output: Contribution to journalArticle

Hascall, VC, Wang, A, Tammi, M, Oikari, S, Tammi, R, Passi, A, Vigetti, D, Hanson, RW & Hart, GW 2014, 'The dynamic metabolism of hyaluronan regulates the cytosolic concentration of UDP-GlcNAc', Matrix Biology, vol. 35, pp. 14-17. https://doi.org/10.1016/j.matbio.2014.01.014
Hascall, Vincent C. ; Wang, Aimin ; Tammi, Markku ; Oikari, Sanna ; Tammi, Raija ; Passi, Alberto ; Vigetti, Davide ; Hanson, Richard W. ; Hart, Gerald Warren. / The dynamic metabolism of hyaluronan regulates the cytosolic concentration of UDP-GlcNAc. In: Matrix Biology. 2014 ; Vol. 35. pp. 14-17.
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