The drug resistance-related protein LRP is the human major vault protein

George L. Scheffer, Peter L J Wijngaard, Marcel J. Flens, Miguel A. Izquierdo, Marilyn L. Slovak, Herbert M. Pinedo, Chris J L M Meijer, Hans C. Clevers, Rik J. Scheper

Research output: Contribution to journalArticle

Abstract

Multidrug-resistant cancer cells frequently overexpress the 110-kD LRP protein (originally named Lung Resistance-related Protein). LRP overexpression has been found to predict a poor response to chemotherapy in acute myeloid leukaemia and ovarian carcinoma. We describe the cloning and chromosome localization of the gene coding for this novel protein. The deduced LRP amino acid sequence shows 87.7% identity with the 104-kD rat major vault protein. Vaults are multi subunit structures that may be involved in nucleo-cytoplasmic transport. The LRP gene is located on chromosome 16, close to the genes coding for multidrug resistance-associated protein and protein kinase c-β, and may mediate drug resistance, perhaps via a transport process.

Original languageEnglish (US)
Pages (from-to)578-582
Number of pages5
JournalNature Medicine
Volume1
Issue number6
DOIs
StatePublished - 1995
Externally publishedYes

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Drug Resistance
Genes
Chromosomes
Pharmaceutical Preparations
Multidrug Resistance-Associated Proteins
Chromosomes, Human, Pair 16
Proteins
Chemotherapy
Cell Nucleus Active Transport
Cloning
Acute Myeloid Leukemia
Protein Kinases
Organism Cloning
Amino Acid Sequence
Cells
Carcinoma
Amino Acids
Drug Therapy
major vault protein
Neoplasms

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Medicine(all)

Cite this

Scheffer, G. L., Wijngaard, P. L. J., Flens, M. J., Izquierdo, M. A., Slovak, M. L., Pinedo, H. M., ... Scheper, R. J. (1995). The drug resistance-related protein LRP is the human major vault protein. Nature Medicine, 1(6), 578-582. https://doi.org/10.1038/nm0695-578

The drug resistance-related protein LRP is the human major vault protein. / Scheffer, George L.; Wijngaard, Peter L J; Flens, Marcel J.; Izquierdo, Miguel A.; Slovak, Marilyn L.; Pinedo, Herbert M.; Meijer, Chris J L M; Clevers, Hans C.; Scheper, Rik J.

In: Nature Medicine, Vol. 1, No. 6, 1995, p. 578-582.

Research output: Contribution to journalArticle

Scheffer, GL, Wijngaard, PLJ, Flens, MJ, Izquierdo, MA, Slovak, ML, Pinedo, HM, Meijer, CJLM, Clevers, HC & Scheper, RJ 1995, 'The drug resistance-related protein LRP is the human major vault protein', Nature Medicine, vol. 1, no. 6, pp. 578-582. https://doi.org/10.1038/nm0695-578
Scheffer GL, Wijngaard PLJ, Flens MJ, Izquierdo MA, Slovak ML, Pinedo HM et al. The drug resistance-related protein LRP is the human major vault protein. Nature Medicine. 1995;1(6):578-582. https://doi.org/10.1038/nm0695-578
Scheffer, George L. ; Wijngaard, Peter L J ; Flens, Marcel J. ; Izquierdo, Miguel A. ; Slovak, Marilyn L. ; Pinedo, Herbert M. ; Meijer, Chris J L M ; Clevers, Hans C. ; Scheper, Rik J. / The drug resistance-related protein LRP is the human major vault protein. In: Nature Medicine. 1995 ; Vol. 1, No. 6. pp. 578-582.
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