The Drosophila dCREB-A gene is required for dorsal/ventral patterning of the larval cuticle

Deborah J. Andrew, Anjum Baig, Purnima Bhanot, Sarah M. Smolik, Katya D. Henderson

Research output: Contribution to journalArticlepeer-review

55 Scopus citations

Abstract

We report on the characterization of the first loss-of-function mutation in a Drosophila CREB gene, dCREB-A. In the epidermis, dCREB-A is required for patterning cuticular structures on both dorsal and ventral surfaces since dCREB-A mutant larvae have only lateral structures around the entire circumference of each segment. Based on results from epistasis tests with known dorsal/ventral patterning genes, we propose that dCREB-A encodes a transcription factor that functions near the end of both the DPP- and SPI-signaling cascades to translate the corresponding extracellular signals into changes in gene expression. The lateralizing phenotype of dCREB-A mutants reveals a much broader function for CREB proteins than previously thought.

Original languageEnglish (US)
Pages (from-to)181-193
Number of pages13
JournalDevelopment
Volume124
Issue number1
StatePublished - Jan 1997

Keywords

  • Cuticle differentiation
  • Dorsal/ventral patterning
  • Drosophila melanogaster
  • Epithelium
  • Salivary gland
  • d-CREBA

ASJC Scopus subject areas

  • Molecular Biology
  • Developmental Biology

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