The dopamine hypothesis of schizophrenia: focus on the dopamine receptor

Research output: Contribution to journalArticle

Abstract

Alleviation of schizophrenic symptoms by phenothiazines and butyrophenones is associated with blockade of dopamine receptors, while exacerbation of symptoms by amphetamines appears to result from enhanced synaptic activity of dopamine and/or norepinephrine. The author suggests that biochemical labeling of the dopamine receptor with 3H dopamine and 3H haloperidol may clarify mechanisms of drug effects on the dopamine receptor.

Original languageEnglish (US)
Pages (from-to)197-202
Number of pages6
JournalAmerican Journal of Psychiatry
Volume133
Issue number2
StatePublished - 1976

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Dopamine Receptors
Dopamine
Schizophrenia
Butyrophenones
Phenothiazines
Amphetamines
Haloperidol
Norepinephrine
Pharmaceutical Preparations

ASJC Scopus subject areas

  • Psychiatry and Mental health

Cite this

The dopamine hypothesis of schizophrenia : focus on the dopamine receptor. / Snyder, Solomon H.

In: American Journal of Psychiatry, Vol. 133, No. 2, 1976, p. 197-202.

Research output: Contribution to journalArticle

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