The dopamine D4 receptor, the ultimate disordered protein

Amina S. Woods

Research output: Contribution to journalArticle

Abstract

The human D4 dopamine receptor is a synaptic neurotransmitter receptor responsible for neuronal signaling in the mesolimbic system of the brain, an area of the brain that regulates emotion and complex behavior. Its structure makes it a very unusual and interesting G protein-coupled receptor (GPCR) as it has several polymorphic variants of its gene in the region encoding the third intracellular loop (IL3). This region contains from two to seven or more similar 48 base pair repeats. These repeats cause this protein to have a very high disorder index and this, in turn, makes it very interactive with other proteins. Among GPCRs in general, the unusually proline-rich IL3 is unique to the D4 receptor (D4R). We believe that, as in the D2R, this region of the receptor plays a role in it's interaction with other receptors.

Original languageEnglish (US)
Pages (from-to)331-336
Number of pages6
JournalJournal of Receptor and Signal Transduction Research
Volume30
Issue number5
DOIs
StatePublished - Oct 2010
Externally publishedYes

Keywords

  • Adenosine A2A Receptor
  • AKAP
  • Disordered proteins
  • Dopamine D Receptor
  • Heteromers

ASJC Scopus subject areas

  • Biochemistry
  • Cell Biology
  • Molecular Biology

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