The Dog Prostate Under Defined Hormonal Influences: An Approach to Experimental Induced Prostatic Growth

H. P. Rohr, D. S. Coffey, D. P. de Klerk, H. P. Woodtli, G. Bartsch

Research output: Contribution to journalArticle

Abstract

The prostate of castrated dogs following treatment with testosterone, dihydrotestosterone and androstanediol combined with 17-β-estradiol application was analyzed by light microscopic stereology. In all three groups there is a statistically significant increase of prostatic volume and weight. There is a statistically significant increase of the relative and absolute volume of the glandular as well as of the stromal part. Seen by the absolute data there is only a statistically significant increase of the volumetric amount of the smooth muscle cells in the dihydrotestosterone and 17-β-estradiol treated animals. Regarding tissue distribution there is no difference between the controls and the castrated testosterone and 17-β-estradiol treated animals. Regarding the stromal part, there is no statistically significant difference between the testosterone and 17-β-estradiol treated group and the control animals. In the androstanediol and 17-β-estradiol group there is a double and in the dihydrotestosterone and 17-β-estradiol group a four-fold increase of the stromal part. The synergistic effect of estrogens and androgens on the growth of both parts of the dog prostate — the glandular and stromal compartment — is discussed.

Original languageEnglish (US)
Pages (from-to)347-361
Number of pages15
JournalPathology Research and Practice
Volume166
Issue number2-3
DOIs
StatePublished - Jan 1 1980

Keywords

  • Androgens
  • Castration
  • Dog
  • Estrogens
  • Morphometry
  • Prostata

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Cell Biology

Fingerprint Dive into the research topics of 'The Dog Prostate Under Defined Hormonal Influences: An Approach to Experimental Induced Prostatic Growth'. Together they form a unique fingerprint.

  • Cite this