The diverse roles of ribbon synapses in sensory neurotransmission

Gary Matthews, Paul Albert Fuchs

Research output: Contribution to journalArticle

Abstract

Sensory synapses of the visual and auditory systems must faithfully encode a wide dynamic range of graded signals, and must be capable of sustained transmitter release over long periods of time. Functionally and morphologically, these sensory synapses are unique: their active zones are specialized in several ways for sustained, rapid vesicle exocytosis, but their most striking feature is an organelle called the synaptic ribbon, which is a proteinaceous structure that extends into the cytoplasm at the active zone and tethers a large pool of releasable vesicles. But precisely how does the ribbon function to support tonic release at these synapses? Recent genetic and biophysical advances have begun to open the 'black box' of the synaptic ribbon with some surprising findings and promise to resolve its function in vision and hearing.

Original languageEnglish (US)
Pages (from-to)812-822
Number of pages11
JournalNature Reviews Neuroscience
Volume11
Issue number12
DOIs
StatePublished - Dec 2010

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Synaptic Transmission
Synapses
Exocytosis
Organelles
Hearing
Cytoplasm

ASJC Scopus subject areas

  • Neuroscience(all)

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The diverse roles of ribbon synapses in sensory neurotransmission. / Matthews, Gary; Fuchs, Paul Albert.

In: Nature Reviews Neuroscience, Vol. 11, No. 12, 12.2010, p. 812-822.

Research output: Contribution to journalArticle

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