The distribution of nitric oxide synthase-containing autonomic preganglionic terminals in the rat

C. R. Anderson, S. L. Edwards, J. B. Furness, D. S. Bredt, S. H. Snyder

Research output: Contribution to journalArticlepeer-review

Abstract

Nitric oxide synthase (NOS)-immunoreactivity was co-localised with NADPH diaphorase activity in preganglionic sympathetic neurons and in their terminals in pre- and paravertebral sympathetic ganglia. The density of NOS-containing terminals varied between ganglia. Reactive terminals were densestin the superior cervical, stellate and inferior mesenteric ganglia, where the majority of the neurons were surrounded by reactive fibres, and the coeliac and superior mesenteric ganglia, where about half the postganglionic somata were sorrounded by reactive terminals. Fibres were least abundant in the pelvic ganglia and thoracic and lumbar sympathetic chain ganglia. NOS reactivity did not coincide with the distribution of calcitonin gene related peptide immunoreactivity, a marker for the terminals of NOS-containing sensory neurons in the rat. The distribution of nerve cells and terminals suggests that NOS is present in more than one functional subpopulation of sympathetic preganglionic neurons.

Original languageEnglish (US)
Pages (from-to)78-85
Number of pages8
JournalBrain research
Volume614
Issue number1-2
DOIs
StatePublished - Jun 18 1993

Keywords

  • Autonomic nervous system
  • Ganglionic transmission
  • NADPH diaphorase
  • Sympathetic postganglionic neuron

ASJC Scopus subject areas

  • Neuroscience(all)
  • Molecular Biology
  • Clinical Neurology
  • Developmental Biology

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