TY - JOUR
T1 - The diffuse-type gastric cancer epidemiology enigma
AU - Assumpção, Paulo Pimentel
AU - Barra, Williams Fernandes
AU - Ishak, Geraldo
AU - Coelho, Luiz Gonzaga Vaz
AU - Coimbra, Felipe José Fernandez
AU - Freitas, Helano Carioca
AU - Dias-Neto, Emmanuel
AU - Camargo, M. Constanza
AU - Szklo, Moyses
N1 - Publisher Copyright:
© 2020 The Author(s).
PY - 2020/7/13
Y1 - 2020/7/13
N2 - Background: Intestinal and diffuse gastric adenocarcinomas differ in clinical, epidemiological and molecular features. However, most of the concepts related to the intestinal-type are translated to gastric adenocarcinoma in general; thus, the peculiarities of the diffuse-type are underappreciated. Results: Besides its growing importance, there are many gaps about the diffuse-type carcinogenesis and, as a result, its epidemiologic and pathogenetic features remain poorly understood. Conclusions: Alternative hypotheses to explain these features are discussed, including the role of the gastric microbiota, medical therapies, and modifications in the stomach's microenvironment.
AB - Background: Intestinal and diffuse gastric adenocarcinomas differ in clinical, epidemiological and molecular features. However, most of the concepts related to the intestinal-type are translated to gastric adenocarcinoma in general; thus, the peculiarities of the diffuse-type are underappreciated. Results: Besides its growing importance, there are many gaps about the diffuse-type carcinogenesis and, as a result, its epidemiologic and pathogenetic features remain poorly understood. Conclusions: Alternative hypotheses to explain these features are discussed, including the role of the gastric microbiota, medical therapies, and modifications in the stomach's microenvironment.
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U2 - 10.1186/s12876-020-01354-4
DO - 10.1186/s12876-020-01354-4
M3 - Review article
C2 - 32660428
AN - SCOPUS:85088045169
SN - 1471-230X
VL - 20
JO - BMC Gastroenterology
JF - BMC Gastroenterology
IS - 1
M1 - 223
ER -