The difference in pharmacokinetics of mitomycin C, given either as a single agent or as a part of combination chemotherapy

J. Verweij; M. Stuurman; J. de Vries; H. M. Pinedo

doi:10.1007/BF00395925

The difference in pharmacokinetics of mitomycin C, given either as a single agent or as a part of combination chemotherapy

J. Verweij, M. Stuurman, J. de Vries, H. M. Pinedo

Research output: Contribution to journal › Article › peer-review

Abstract

In a previous report it was suggested that the total body clearance of mitomycin C (MMC) was different after single agent treatment compared to combination chemotherapy. This suggestion was based on recalculations to one dose level. In the present study a fixed dose of 10 mg/m² was used. Seven patients on single agent MMC and eight on combination chemotherapy were studied. Terminal half-life varied from 25 to 78 mm, volume of distribution from 7 to 73 l/m², total body clearance from 11 to 56 l/h per m², and area under the plasma concentration-time curve (AUC) from 177 to 933 μg/h per 1. Total body clearance was significantly higher and AUC significantly lower in patients on combination chemotherapy. The cause of this difference was not investigated.

Original language	English (US)
Pages (from-to)	283-284
Number of pages	2
Journal	Journal of Cancer Research and Clinical Oncology
Volume	112
Issue number	3
DOIs	https://doi.org/10.1007/BF00395925
State	Published - Nov 1986
Externally published	Yes

Keywords

Combination chemotherapy
Mitomycin C
Pharmacokinetics

ASJC Scopus subject areas

Oncology
Cancer Research

Access to Document

10.1007/BF00395925

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title = "The difference in pharmacokinetics of mitomycin C, given either as a single agent or as a part of combination chemotherapy",

abstract = "In a previous report it was suggested that the total body clearance of mitomycin C (MMC) was different after single agent treatment compared to combination chemotherapy. This suggestion was based on recalculations to one dose level. In the present study a fixed dose of 10 mg/m2 was used. Seven patients on single agent MMC and eight on combination chemotherapy were studied. Terminal half-life varied from 25 to 78 mm, volume of distribution from 7 to 73 l/m2, total body clearance from 11 to 56 l/h per m2, and area under the plasma concentration-time curve (AUC) from 177 to 933 μg/h per 1. Total body clearance was significantly higher and AUC significantly lower in patients on combination chemotherapy. The cause of this difference was not investigated.",

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AU - Verweij, J.

AU - Stuurman, M.

AU - de Vries, J.

AU - Pinedo, H. M.

PY - 1986/11

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AB - In a previous report it was suggested that the total body clearance of mitomycin C (MMC) was different after single agent treatment compared to combination chemotherapy. This suggestion was based on recalculations to one dose level. In the present study a fixed dose of 10 mg/m2 was used. Seven patients on single agent MMC and eight on combination chemotherapy were studied. Terminal half-life varied from 25 to 78 mm, volume of distribution from 7 to 73 l/m2, total body clearance from 11 to 56 l/h per m2, and area under the plasma concentration-time curve (AUC) from 177 to 933 μg/h per 1. Total body clearance was significantly higher and AUC significantly lower in patients on combination chemotherapy. The cause of this difference was not investigated.

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