Abstract
In a previous report it was suggested that the total body clearance of mitomycin C (MMC) was different after single agent treatment compared to combination chemotherapy. This suggestion was based on recalculations to one dose level. In the present study a fixed dose of 10 mg/m2 was used. Seven patients on single agent MMC and eight on combination chemotherapy were studied. Terminal half-life varied from 25 to 78 mm, volume of distribution from 7 to 73 l/m2, total body clearance from 11 to 56 l/h per m2, and area under the plasma concentration-time curve (AUC) from 177 to 933 μg/h per 1. Total body clearance was significantly higher and AUC significantly lower in patients on combination chemotherapy. The cause of this difference was not investigated.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 283-284 |
| Number of pages | 2 |
| Journal | Journal of Cancer Research and Clinical Oncology |
| Volume | 112 |
| Issue number | 3 |
| DOIs | |
| State | Published - Nov 1986 |
| Externally published | Yes |
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Keywords
- Combination chemotherapy
- Mitomycin C
- Pharmacokinetics
ASJC Scopus subject areas
- Oncology
- Cancer Research
Cite this
The difference in pharmacokinetics of mitomycin C, given either as a single agent or as a part of combination chemotherapy. / Verweij, J.; Stuurman, M.; de Vries, J.; Pinedo, H. M.
In: Journal of Cancer Research and Clinical Oncology, Vol. 112, No. 3, 11.1986, p. 283-284.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - The difference in pharmacokinetics of mitomycin C, given either as a single agent or as a part of combination chemotherapy
AU - Verweij, J.
AU - Stuurman, M.
AU - de Vries, J.
AU - Pinedo, H. M.
PY - 1986/11
Y1 - 1986/11
N2 - In a previous report it was suggested that the total body clearance of mitomycin C (MMC) was different after single agent treatment compared to combination chemotherapy. This suggestion was based on recalculations to one dose level. In the present study a fixed dose of 10 mg/m2 was used. Seven patients on single agent MMC and eight on combination chemotherapy were studied. Terminal half-life varied from 25 to 78 mm, volume of distribution from 7 to 73 l/m2, total body clearance from 11 to 56 l/h per m2, and area under the plasma concentration-time curve (AUC) from 177 to 933 μg/h per 1. Total body clearance was significantly higher and AUC significantly lower in patients on combination chemotherapy. The cause of this difference was not investigated.
AB - In a previous report it was suggested that the total body clearance of mitomycin C (MMC) was different after single agent treatment compared to combination chemotherapy. This suggestion was based on recalculations to one dose level. In the present study a fixed dose of 10 mg/m2 was used. Seven patients on single agent MMC and eight on combination chemotherapy were studied. Terminal half-life varied from 25 to 78 mm, volume of distribution from 7 to 73 l/m2, total body clearance from 11 to 56 l/h per m2, and area under the plasma concentration-time curve (AUC) from 177 to 933 μg/h per 1. Total body clearance was significantly higher and AUC significantly lower in patients on combination chemotherapy. The cause of this difference was not investigated.
KW - Combination chemotherapy
KW - Mitomycin C
KW - Pharmacokinetics
UR - http://www.scopus.com/inward/record.url?scp=0022917402&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0022917402&partnerID=8YFLogxK
U2 - 10.1007/BF00395925
DO - 10.1007/BF00395925
M3 - Article
C2 - 3097025
AN - SCOPUS:0022917402
VL - 112
SP - 283
EP - 284
JO - Journal of Cancer Research and Clinical Oncology
JF - Journal of Cancer Research and Clinical Oncology
SN - 0171-5216
IS - 3
ER -