Abstract
In a previous report it was suggested that the total body clearance of mitomycin C (MMC) was different after single agent treatment compared to combination chemotherapy. This suggestion was based on recalculations to one dose level. In the present study a fixed dose of 10 mg/m2 was used. Seven patients on single agent MMC and eight on combination chemotherapy were studied. Terminal half-life varied from 25 to 78 mm, volume of distribution from 7 to 73 l/m2, total body clearance from 11 to 56 l/h per m2, and area under the plasma concentration-time curve (AUC) from 177 to 933 μg/h per 1. Total body clearance was significantly higher and AUC significantly lower in patients on combination chemotherapy. The cause of this difference was not investigated.
Original language | English (US) |
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Pages (from-to) | 283-284 |
Number of pages | 2 |
Journal | Journal of Cancer Research and Clinical Oncology |
Volume | 112 |
Issue number | 3 |
DOIs | |
State | Published - Nov 1986 |
Externally published | Yes |
Keywords
- Combination chemotherapy
- Mitomycin C
- Pharmacokinetics
ASJC Scopus subject areas
- Oncology
- Cancer Research