The diagnostic role of claudins in serous effusions

Lilach Kleinberg, Arild Holth, Eduard Fridman, Ignat Schwartz, Ie Ming Shih, Ben Davidson

Research output: Contribution to journalArticle

Abstract

We analyzed the diagnostic role of claudins in effusion cytology in 325 effusions, including 218 ovarian, 49 breast, 15 cervical or endometrial, 10 gastrointestinal, and 8 lung adenocarcinomas and 25 malignant mesotheliomas (MMs). Specimens were analyzed for claudin-1 and claudin-3 expression using immunohistochemical analysis. Ovarian and breast adenocarcinoma were further analyzed for claudin-7 expression. Claudin-1 expression was most frequent in ovarian and cervical or endometrial adenocarcinoma compared with other adenocarcinomas and MMs (P <.001). Claudin-3 expression was comparable in adenocarcinomas of different origin but was absent in MMs (P <.001). Reactive mesothelial cells rarely expressed claudins. Claudin-7 expression was higher in ovarian than in breast adenocarcinoma (P <.001). Our data suggest that expression of claudin-3 or claudin-7 is specific for adenocarcinoma and rules out the diagnosis of cells as mesothelial and that absence of claudin-1 expression excludes ovarian carcinoma as the possible origin of metastatic adenocarcinoma. Claudins may, therefore, be of diagnostic value in effusion cytology.

Original languageEnglish (US)
Pages (from-to)928-937
Number of pages10
JournalAmerican Journal of Clinical Pathology
Volume127
Issue number6
DOIs
StatePublished - Jun 2007

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Claudins
Adenocarcinoma
Claudin-3
Claudin-1
Breast
Cell Biology
Carcinoma

Keywords

  • Adenocarcinoma
  • Claudins
  • Effusions
  • Mesothelioma

ASJC Scopus subject areas

  • Pathology and Forensic Medicine

Cite this

Kleinberg, L., Holth, A., Fridman, E., Schwartz, I., Shih, I. M., & Davidson, B. (2007). The diagnostic role of claudins in serous effusions. American Journal of Clinical Pathology, 127(6), 928-937. https://doi.org/10.1309/V025QRN3R9CJGNPX

The diagnostic role of claudins in serous effusions. / Kleinberg, Lilach; Holth, Arild; Fridman, Eduard; Schwartz, Ignat; Shih, Ie Ming; Davidson, Ben.

In: American Journal of Clinical Pathology, Vol. 127, No. 6, 06.2007, p. 928-937.

Research output: Contribution to journalArticle

Kleinberg, L, Holth, A, Fridman, E, Schwartz, I, Shih, IM & Davidson, B 2007, 'The diagnostic role of claudins in serous effusions', American Journal of Clinical Pathology, vol. 127, no. 6, pp. 928-937. https://doi.org/10.1309/V025QRN3R9CJGNPX
Kleinberg, Lilach ; Holth, Arild ; Fridman, Eduard ; Schwartz, Ignat ; Shih, Ie Ming ; Davidson, Ben. / The diagnostic role of claudins in serous effusions. In: American Journal of Clinical Pathology. 2007 ; Vol. 127, No. 6. pp. 928-937.
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