@article{c2934f61db5e41d6bca4b5f3a3dc30a1,
title = "The Developmental Chronnecto-Genomics (Dev-CoG) study: A multimodal study on the developing brain",
abstract = "Brain development has largely been studied through unimodal analysis of neuroimaging data, providing independent results for structural and functional data. However, structure clearly impacts function and vice versa, pointing to the need for performing multimodal data collection and analysis to improve our understanding of brain development, and to further inform models of typical and atypical brain development across the lifespan. Ultimately, such models should also incorporate genetic and epigenetic mechanisms underlying brain structure and function, although currently this area is poorly specified. To this end, we are reporting here a multi-site, multi-modal dataset that captures cognitive function, brain structure and function, and genetic and epigenetic measures to better quantify the factors that influence brain development in children originally aged 9–14 years. Data collection for the Developmental Chronnecto-Genomics (Dev-CoG) study (http://devcog.mrn.org/) includes cognitive, emotional, and social performance scales, structural and functional MRI, diffusion MRI, magnetoencephalography (MEG), and saliva collection for DNA analysis of single nucleotide polymorphisms (SNPs) and DNA methylation patterns. Across two sites (The Mind Research Network and the University of Nebraska Medical Center), data from over 200 participants were collected and these children were re-tested annually for at least 3 years. The data collection protocol, sample demographics, and data quality measures for the dataset are presented here. The sample will be made freely available through the collaborative informatics and neuroimaging suite (COINS) database at the conclusion of the study.",
keywords = "Adolescence, Epigenetics, FMRI, Genetics, MRI, Magnetoencephalography, Neurodevelopment, Resting-state",
author = "Stephen, {J. M.} and I. Solis and J. Janowich and M. Stern and Frenzel, {M. R.} and Eastman, {J. A.} and Mills, {M. S.} and Embury, {C. M.} and Coolidge, {N. M.} and E. Heinrichs-Graham and A. Mayer and J. Liu and Wang, {Y. P.} and Wilson, {T. W.} and Calhoun, {V. D.}",
note = "Funding Information: We wish to thank the participants and their parents for their willingness to participate in this longitudinal study on brain development. Funding: This work was supported by the National Science Foundation [Grant number 1539067 ] and National Institute of Health [Grant numbers: R01-MH121101 , P20-GM130447 , P30GM122734, P50AA22534 ]. Funding Information: The cohort was recruited from two sites: The Mind Research Network (MRN) located in Albuquerque, New Mexico and the University of Nebraska Medical Center (UNMC) located in Omaha, Nebraska. The study is funded through the National Science Foundation's Established Program to Stimulate Competitive Research (NSF EPSCoR), which is designed to increase research capacity within a subset of states in the USA. The studies were approved by the relevant institutional review board at each data collection site (Advarrra IRB – MRN and UNMC IRB – Nebraska) and data sharing across study sites was written into the consent forms and the study protocols. All study protocols were approved by the IRB prior to study initiation and the research was carried out in compliance with the Declaration of Helsinki. The de-identified dataset will be made available to the broader research community at the completion of the study. Funding Information: We wish to thank the participants and their parents for their willingness to participate in this longitudinal study on brain development. Funding: This work was supported by the National Science Foundation [Grant number 1539067] and National Institute of Health [Grant numbers: R01-MH121101, P20-GM130447, P30GM122734, P50AA22534]. All authors reviewed and contributed to the manuscript, Stephen, JM ? MPI of the study, contributed to the study design, oversaw NM data collection, wrote the manuscript, Solis, I, Janowich, J, Stern, M ? Participated in data collection in NM, contributed tables and description of behavioral and cognitive assessments for the manuscript, MEG and MRI method details and participant demographic information for the manuscript, Frenzel, MR, Eastman, JA, Mills, MS, Embury, CM, Coolidge NM, Heinrichs-Graham, E ? Participated in data collection in NE, contributed tables and description of behavioral and cognitive assessments for the manuscript, MEG and MRI method details and participant demographic information for the manuscript. Mayer, AR ? Provided expertise on cognitive assessment of children 9?14 years of age as a clinical psychologist, Wilson, TW ? MPI of the study, contributed to the study design, oversaw NE data collection, Wang, YP ? MPI of the study, contributed to the study design, developed analysis methods, Calhoun, VD ? PI of the study, contributed to the study design, developed analysis methods Publisher Copyright: {\textcopyright} 2020",
year = "2021",
month = jan,
day = "15",
doi = "10.1016/j.neuroimage.2020.117438",
language = "English (US)",
volume = "225",
journal = "NeuroImage",
issn = "1053-8119",
publisher = "Academic Press Inc.",
}