The development of the pathologic changes of Alzheimer's disease and senile dementia in patients with Down's syndrome

P. C. Burger, F. S. Vogel

Research output: Contribution to journalArticlepeer-review

Abstract

Senile plaques, neurofibrillary change and granulovacuolar degeneration characterize Alzheimer's disease (presenile dementia) and senile dementia and are also seen in the aged human brain. The development of these lesions was studied in 13 patients with Down's syndrome, ages 12 to 65, with the purpose of defining similarities and dissimilarities, if any, between their morphologies in the 4 conditions. Evaluation by light and, when applied, electron microscopy established apparent identities. The findings suggest that Down's syndrome, with its partially characterized genotypic and phenotypic abnormalities, is an appropriate model for the study of the pathogenesis of these lesions.

Original languageEnglish (US)
Pages (from-to)457-476
Number of pages20
JournalAmerican Journal of Pathology
Volume73
Issue number2
StatePublished - Dec 1 1973

ASJC Scopus subject areas

  • Pathology and Forensic Medicine

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