The development of neurobiological models for cognitive decline in aging

Michela Gallagher, T. Michael Gill, Mark G. Baxter, David J. Bucci

Research output: Contribution to journalArticlepeer-review

Abstract

Neurobiological models are important for identifying the effects of aging that contribute to cognitive decline and for developing interventions to either prevent those changes or restore more optimal function. As a starting point, this paper considers one type of approach using cholinergic deficiency within the hippocampal system as a model for age-related spatial learning impairment. It is suggested that this approach, based on producing a target lesion in the brain, is inadequate for investigating the aging process. As an alternative, a systems-level approach to the development of more useful and accurate models of neurobiological aging is advocated.

Original languageEnglish (US)
Pages (from-to)351-358
Number of pages8
JournalSeminars in Neuroscience
Volume6
Issue number6
DOIs
StatePublished - Dec 1994
Externally publishedYes

Keywords

  • Aging
  • Cholinergic
  • Hippocampus
  • Rat
  • Spatial

ASJC Scopus subject areas

  • Neuroscience(all)

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