TY - JOUR
T1 - The development of negative skin tests in children treated with venom immunotherapy
AU - Graft, David F.
AU - Schuberth, Kenneth C.
AU - Kagey-Sobotka, Anne
AU - Kwiterovich, Kathy A.
AU - Niv, Yaffa
AU - Lichtenstein, Lawrence M.
AU - Valentine, Martin D.
N1 - Funding Information:
From the Departments of Medicine and Pediatrics, The Johns Hopkins University School of Medicine at The Good Samaritan Hospitai Supported by Grant AI 15443 from the National Institutes of Health. Received for publication April 20, 1983. Accepted for Publication July 20, 1983. Reprint requests: Martin D. Valentine, M.D., Division of Clinical Immunology, Johns Hopkins University School of Medicine at the Good Samaritan Hospital, 5601 Loch Raven Blvd., Balti-more, MD 21239. *Publication No. 540 from the O’Neill Laboratories.
PY - 1984/1
Y1 - 1984/1
N2 - Twenty-eight of 62 children (45%) with a history of sting-induced anaphylaxis and initially positive skin tests to venom(s) developed negative venom skin tests to one or more of the venoms used in their treatment after 3 yr or more of immunotherapy. Children who developed negative venom skin tests were less sensitive prior to treatment, as judged by venom skin tests and venom specific IgE antibody determinations, than children who maintained positive venom skin tests. Levels of venom-specific IgE antibodies declined with time in most children, but to lower levels in those with negative skin tests. Venom specific IgG antibody levels were similar in both patients with negative skin tests and those with persistently positive skin tests. The development of negative skin tests may reflect a loss of allergic sensitivity, which is sufficient to allow the physician to consider the discontinuation of venom injections.
AB - Twenty-eight of 62 children (45%) with a history of sting-induced anaphylaxis and initially positive skin tests to venom(s) developed negative venom skin tests to one or more of the venoms used in their treatment after 3 yr or more of immunotherapy. Children who developed negative venom skin tests were less sensitive prior to treatment, as judged by venom skin tests and venom specific IgE antibody determinations, than children who maintained positive venom skin tests. Levels of venom-specific IgE antibodies declined with time in most children, but to lower levels in those with negative skin tests. Venom specific IgG antibody levels were similar in both patients with negative skin tests and those with persistently positive skin tests. The development of negative skin tests may reflect a loss of allergic sensitivity, which is sufficient to allow the physician to consider the discontinuation of venom injections.
UR - http://www.scopus.com/inward/record.url?scp=0021355169&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0021355169&partnerID=8YFLogxK
U2 - 10.1016/0091-6749(84)90485-8
DO - 10.1016/0091-6749(84)90485-8
M3 - Article
C2 - 6693669
AN - SCOPUS:0021355169
SN - 0091-6749
VL - 73
SP - 61
EP - 68
JO - The Journal of allergy and clinical immunology
JF - The Journal of allergy and clinical immunology
IS - 1 PART 1
ER -