The development of negative skin tests in children treated with venom immunotherapy

David F. Graft, Kenneth C Schuberth, Anne Kagey-Sobotka, Kathy A. Kwiterovich, Yaffa Niv, Lawrence M. Lichtenstein, Martin D. Valentine

Research output: Contribution to journalArticle

Abstract

Twenty-eight of 62 children (45%) with a history of sting-induced anaphylaxis and initially positive skin tests to venom(s) developed negative venom skin tests to one or more of the venoms used in their treatment after 3 yr or more of immunotherapy. Children who developed negative venom skin tests were less sensitive prior to treatment, as judged by venom skin tests and venom specific IgE antibody determinations, than children who maintained positive venom skin tests. Levels of venom-specific IgE antibodies declined with time in most children, but to lower levels in those with negative skin tests. Venom specific IgG antibody levels were similar in both patients with negative skin tests and those with persistently positive skin tests. The development of negative skin tests may reflect a loss of allergic sensitivity, which is sufficient to allow the physician to consider the discontinuation of venom injections.

Original languageEnglish (US)
Pages (from-to)61-68
Number of pages8
JournalThe Journal of Allergy and Clinical Immunology
Volume73
Issue number1 PART 1
DOIs
StatePublished - 1984

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Venoms
Skin Tests
Immunotherapy
Immunoglobulin E
Antibodies
Anaphylaxis
Bites and Stings
Immunoglobulin G
Physicians
Injections

ASJC Scopus subject areas

  • Immunology
  • Immunology and Allergy

Cite this

The development of negative skin tests in children treated with venom immunotherapy. / Graft, David F.; Schuberth, Kenneth C; Kagey-Sobotka, Anne; Kwiterovich, Kathy A.; Niv, Yaffa; Lichtenstein, Lawrence M.; Valentine, Martin D.

In: The Journal of Allergy and Clinical Immunology, Vol. 73, No. 1 PART 1, 1984, p. 61-68.

Research output: Contribution to journalArticle

Graft, David F. ; Schuberth, Kenneth C ; Kagey-Sobotka, Anne ; Kwiterovich, Kathy A. ; Niv, Yaffa ; Lichtenstein, Lawrence M. ; Valentine, Martin D. / The development of negative skin tests in children treated with venom immunotherapy. In: The Journal of Allergy and Clinical Immunology. 1984 ; Vol. 73, No. 1 PART 1. pp. 61-68.
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