The development of local circuits in the neocortex: recent lessons from the mouse visual cortex

Maxime Chevée, Solange P. Brown

Research output: Contribution to journalReview articlepeer-review

Abstract

Precise synaptic connections among neurons in the neocortex generate the circuits that underlie a broad repertoire of cortical functions including perception, learning and memory, and complex problem solving. The specific patterns and properties of these synaptic connections are fundamental to the computations cortical neurons perform. How such specificity arises in cortical circuits has remained elusive. Here, we first consider the cell-type, subcellular and synaptic specificity required for generating mature patterns of cortical connectivity and responses. Next, we focus on recent progress in understanding how the synaptic connections among excitatory cortical projection neurons are established during development using the primary visual cortex of the mouse as a model.

Original languageEnglish (US)
Pages (from-to)103-109
Number of pages7
JournalCurrent Opinion in Neurobiology
Volume53
DOIs
StatePublished - Dec 2018

ASJC Scopus subject areas

  • Neuroscience(all)

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