The deubiquitinase USP44 is a tumor suppressor that protects against chromosome missegregation

Andrew J. Holland, Don W. Cleveland

Research output: Contribution to journalComment/debatepeer-review

Abstract

The mitotic checkpoint plays an important role in preventing chromosome segregation errors and the production of aneuploid progeny. In this issue, Zhang et al. examine mice and cells lacking the deubiquitinating enzyme USP44. Surprisingly, they find that USP44 prevents chromosome segregation errors through a function independent of its previously identified role in the mitotic checkpoint. Usp44-null animals develop aneuploidy and experience increased rates of tumorigenesis, implicating USP44 as novel tumor suppressor.

Original languageEnglish (US)
Pages (from-to)4325-4328
Number of pages4
JournalJournal of Clinical Investigation
Volume122
Issue number12
DOIs
StatePublished - Dec 3 2012

ASJC Scopus subject areas

  • Medicine(all)

Fingerprint Dive into the research topics of 'The deubiquitinase USP44 is a tumor suppressor that protects against chromosome missegregation'. Together they form a unique fingerprint.

Cite this