The detrimental effects of delayed graft function in cadaver donor renal transplantation

Fred Sanfilippo, William K. Vaughn, Everett K. Spees, Bruce A. Lucas

Research output: Contribution to journalArticlepeer-review


Data collected prospectively on over 3800 cadaveric renal transplants performed between June 1977 and July 1982 by the 41 member institutions of the South-Eastern Organ Procurement Foundation were analyzed to determine the influence of delayed graft function (DGF) on patient and graft outcome. Approximately 35% of first graft recipients and 47% of regrafted patients were found to have DGF, as determined by the necessity for dialysis at one week posttransplant. First-graft recipients with DGF tended to include more black recipients, patients with higher peak levels of panel reactive antibody (PRA), less use of antilymphocyte serum (ALS) posttransplant, slightly longer organ preservation times and the more frequent use of organs preserved by ice alone. Multivariate (Cox) regression analysis considering DGF simultaneously with ten other potentially confounding variables showed a highly significant association between DGF and overall graft loss from all causes (P-5), irreversible graft rejection (P

Original languageEnglish (US)
Pages (from-to)643-648
Number of pages6
Issue number6
StatePublished - 1984
Externally publishedYes

ASJC Scopus subject areas

  • Transplantation
  • Immunology


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