The design and evaluation of HIV-1 vaccines

Kevin O. Saunders, Rebecca S. Rudicell, Gary J. Nabel

Research output: Contribution to journalArticle

Abstract

There is renewed optimism that the goal of developing a highly effective AIDS vaccine is attainable. The HIV-1 vaccine field has seen its first trial of a vaccine candidate that prevents infection. Although modest in efficacy, this finding, along with the recent discovery that the human immune system can produce broadly neutralizing antibodies capable of inhibiting greater than 90% of circulating viruses, provides a guide for the rational design of vaccines and protection by passive immunization. Together, these findings will help shape the next generation of HIV vaccines.

Original languageEnglish (US)
Pages (from-to)1293-1302
Number of pages10
JournalAIDS
Volume26
Issue number10
DOIs
StatePublished - Jun 19 2012
Externally publishedYes

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Keywords

  • clinical trials
  • HIV-1
  • immunogen design
  • vaccine

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology
  • Infectious Diseases

Cite this

Saunders, K. O., Rudicell, R. S., & Nabel, G. J. (2012). The design and evaluation of HIV-1 vaccines. AIDS, 26(10), 1293-1302. https://doi.org/10.1097/QAD.0b013e32835474d2