The depressant scorpion neurotoxin LqqIT2 selectively modulates the insect voltage-gated sodium channel

Frank Bosmans, Marie France Martin-Eauclaire, Jan Tytgat

Research output: Contribution to journalArticlepeer-review

Abstract

LqqIT2 is a depressant neurotoxin present in the venom of the Leiurus quinquestriatus quinquestriatus scorpion, one of the world's most dangerous scorpions endemic to dry habitats in Africa and Asia. In order to determine its efficacy, potency and selectivity, LqqIT2 was subjected for the first time to an electrophysiological and pharmacological comparison between two different cloned sodium channels expressed in Xenopus laevis oocytes. Aside from typical β-toxin effects, LqqIT2 also affected the inactivation process and ion selectivity of the insect voltage-gated sodium channel. The most interesting feature of LqqIT2 is its total insect-selectivity. At a concentration of 1 μM, the insect-voltage-gated sodium channel, para, was profoundly modulated while its mammalian counterpart, the rat brain Nav1.2 channel, was not affected. This trait offers excellent prospects for the development of novel insecticides.

Original languageEnglish (US)
Pages (from-to)501-507
Number of pages7
JournalToxicon
Volume45
Issue number4
DOIs
StatePublished - Mar 15 2005

Keywords

  • Depressant scorpion toxin
  • Insecticide
  • LqqIT2

ASJC Scopus subject areas

  • Toxicology

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