The degradation of cyanoacrylate tissue adhesive. I

John L. Cameron; Stephen C. Woodward; Edwin J. Pulaski; H. Kenneth Sleeman; George Brandes; Ramchandra K. Kulkarni; Fred Leonard

The degradation of cyanoacrylate tissue adhesive. I

John L. Cameron, Stephen C. Woodward, Edwin J. Pulaski, H. Kenneth Sleeman, George Brandes, Ramchandra K. Kulkarni, Fred Leonard

Research output: Contribution to journal › Article › peer-review

Abstract

Radioactive C¹⁴ methyl-2-cyanoacrylate has been implanted in rats and its in vivo degradation has been studied with the use of radiotracer techniques. The data indicate that the polymer is degraded and radioactive entities are eliminated in the urine and feces. No radioactive entities have been found remaining in the tissues and vital organs. A possible mechanism for the degradation of the polymer based on hydrolytic attack at a carbon-carbon bond to produce formaldehyde and resulting chain cleavage has been discussed.

Original language	English (US)
Pages (from-to)	424-430
Number of pages	7
Journal	Surgery
Volume	58
Issue number	2
State	Published - Aug 1965
Externally published	Yes

ASJC Scopus subject areas

Surgery

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title = "The degradation of cyanoacrylate tissue adhesive. I",

abstract = "Radioactive C14 methyl-2-cyanoacrylate has been implanted in rats and its in vivo degradation has been studied with the use of radiotracer techniques. The data indicate that the polymer is degraded and radioactive entities are eliminated in the urine and feces. No radioactive entities have been found remaining in the tissues and vital organs. A possible mechanism for the degradation of the polymer based on hydrolytic attack at a carbon-carbon bond to produce formaldehyde and resulting chain cleavage has been discussed.",

author = "Cameron, {John L.} and Woodward, {Stephen C.} and Pulaski, {Edwin J.} and Sleeman, {H. Kenneth} and George Brandes and Kulkarni, {Ramchandra K.} and Fred Leonard",

year = "1965",

month = aug,

language = "English (US)",

volume = "58",

pages = "424--430",

journal = "Surgery",

issn = "0039-6060",

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T1 - The degradation of cyanoacrylate tissue adhesive. I

AU - Cameron, John L.

AU - Woodward, Stephen C.

AU - Pulaski, Edwin J.

AU - Sleeman, H. Kenneth

AU - Brandes, George

AU - Kulkarni, Ramchandra K.

AU - Leonard, Fred

PY - 1965/8

Y1 - 1965/8

N2 - Radioactive C14 methyl-2-cyanoacrylate has been implanted in rats and its in vivo degradation has been studied with the use of radiotracer techniques. The data indicate that the polymer is degraded and radioactive entities are eliminated in the urine and feces. No radioactive entities have been found remaining in the tissues and vital organs. A possible mechanism for the degradation of the polymer based on hydrolytic attack at a carbon-carbon bond to produce formaldehyde and resulting chain cleavage has been discussed.

AB - Radioactive C14 methyl-2-cyanoacrylate has been implanted in rats and its in vivo degradation has been studied with the use of radiotracer techniques. The data indicate that the polymer is degraded and radioactive entities are eliminated in the urine and feces. No radioactive entities have been found remaining in the tissues and vital organs. A possible mechanism for the degradation of the polymer based on hydrolytic attack at a carbon-carbon bond to produce formaldehyde and resulting chain cleavage has been discussed.

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