The degradation of cyanoacrylate tissue adhesive. I

John L. Cameron, Stephen C. Woodward, Edwin J. Pulaski, H. Kenneth Sleeman, George Brandes, Ramchandra K. Kulkarni, Fred Leonard

Research output: Contribution to journalArticlepeer-review


Radioactive C14 methyl-2-cyanoacrylate has been implanted in rats and its in vivo degradation has been studied with the use of radiotracer techniques. The data indicate that the polymer is degraded and radioactive entities are eliminated in the urine and feces. No radioactive entities have been found remaining in the tissues and vital organs. A possible mechanism for the degradation of the polymer based on hydrolytic attack at a carbon-carbon bond to produce formaldehyde and resulting chain cleavage has been discussed.

Original languageEnglish (US)
Pages (from-to)424-430
Number of pages7
Issue number2
StatePublished - Aug 1965
Externally publishedYes

ASJC Scopus subject areas

  • Surgery


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