Abstract
Radioactive C14 methyl-2-cyanoacrylate has been implanted in rats and its in vivo degradation has been studied with the use of radiotracer techniques. The data indicate that the polymer is degraded and radioactive entities are eliminated in the urine and feces. No radioactive entities have been found remaining in the tissues and vital organs. A possible mechanism for the degradation of the polymer based on hydrolytic attack at a carbon-carbon bond to produce formaldehyde and resulting chain cleavage has been discussed.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 424-430 |
| Number of pages | 7 |
| Journal | Surgery |
| Volume | 58 |
| Issue number | 2 |
| State | Published - Aug 1965 |
| Externally published | Yes |
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ASJC Scopus subject areas
- Surgery
Cite this
The degradation of cyanoacrylate tissue adhesive. I. / Cameron, John L; Woodward, Stephen C.; Pulaski, Edwin J.; Sleeman, H. Kenneth; Brandes, George; Kulkarni, Ramchandra K.; Leonard, Fred.
In: Surgery, Vol. 58, No. 2, 08.1965, p. 424-430.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - The degradation of cyanoacrylate tissue adhesive. I
AU - Cameron, John L
AU - Woodward, Stephen C.
AU - Pulaski, Edwin J.
AU - Sleeman, H. Kenneth
AU - Brandes, George
AU - Kulkarni, Ramchandra K.
AU - Leonard, Fred
PY - 1965/8
Y1 - 1965/8
N2 - Radioactive C14 methyl-2-cyanoacrylate has been implanted in rats and its in vivo degradation has been studied with the use of radiotracer techniques. The data indicate that the polymer is degraded and radioactive entities are eliminated in the urine and feces. No radioactive entities have been found remaining in the tissues and vital organs. A possible mechanism for the degradation of the polymer based on hydrolytic attack at a carbon-carbon bond to produce formaldehyde and resulting chain cleavage has been discussed.
AB - Radioactive C14 methyl-2-cyanoacrylate has been implanted in rats and its in vivo degradation has been studied with the use of radiotracer techniques. The data indicate that the polymer is degraded and radioactive entities are eliminated in the urine and feces. No radioactive entities have been found remaining in the tissues and vital organs. A possible mechanism for the degradation of the polymer based on hydrolytic attack at a carbon-carbon bond to produce formaldehyde and resulting chain cleavage has been discussed.
UR - http://www.scopus.com/inward/record.url?scp=0005775587&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0005775587&partnerID=8YFLogxK
M3 - Article
VL - 58
SP - 424
EP - 430
JO - Surgery
JF - Surgery
SN - 0039-6060
IS - 2
ER -