The degradation of cyanoacrylate tissue adhesive. I

John L Cameron, Stephen C. Woodward, Edwin J. Pulaski, H. Kenneth Sleeman, George Brandes, Ramchandra K. Kulkarni, Fred Leonard

Research output: Contribution to journalArticle

Abstract

Radioactive C14 methyl-2-cyanoacrylate has been implanted in rats and its in vivo degradation has been studied with the use of radiotracer techniques. The data indicate that the polymer is degraded and radioactive entities are eliminated in the urine and feces. No radioactive entities have been found remaining in the tissues and vital organs. A possible mechanism for the degradation of the polymer based on hydrolytic attack at a carbon-carbon bond to produce formaldehyde and resulting chain cleavage has been discussed.

LanguageEnglish (US)
Pages424-430
Number of pages7
JournalSurgery
Volume58
Issue number2
StatePublished - Aug 1965
Externally publishedYes

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Tissue Adhesives
Cyanoacrylates
Polymers
Carbon
Feces
Formaldehyde
Urine
methyl 2-cyanoacrylate

ASJC Scopus subject areas

  • Surgery

Cite this

Cameron, J. L., Woodward, S. C., Pulaski, E. J., Sleeman, H. K., Brandes, G., Kulkarni, R. K., & Leonard, F. (1965). The degradation of cyanoacrylate tissue adhesive. I. Surgery, 58(2), 424-430.

The degradation of cyanoacrylate tissue adhesive. I. / Cameron, John L; Woodward, Stephen C.; Pulaski, Edwin J.; Sleeman, H. Kenneth; Brandes, George; Kulkarni, Ramchandra K.; Leonard, Fred.

In: Surgery, Vol. 58, No. 2, 08.1965, p. 424-430.

Research output: Contribution to journalArticle

Cameron, JL, Woodward, SC, Pulaski, EJ, Sleeman, HK, Brandes, G, Kulkarni, RK & Leonard, F 1965, 'The degradation of cyanoacrylate tissue adhesive. I', Surgery, vol. 58, no. 2, pp. 424-430.
Cameron JL, Woodward SC, Pulaski EJ, Sleeman HK, Brandes G, Kulkarni RK et al. The degradation of cyanoacrylate tissue adhesive. I. Surgery. 1965 Aug;58(2):424-430.
Cameron, John L ; Woodward, Stephen C. ; Pulaski, Edwin J. ; Sleeman, H. Kenneth ; Brandes, George ; Kulkarni, Ramchandra K. ; Leonard, Fred. / The degradation of cyanoacrylate tissue adhesive. I. In: Surgery. 1965 ; Vol. 58, No. 2. pp. 424-430.
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