The cyclolinopeptide A analogues with D-Phe, D-Tyr, and L- and D-Trp residues

M. Cebrat, M. Lisowski, I. Z. Siemion, Z. Wieczorek

Research output: Contribution to journalArticlepeer-review


A series of nine linear and nine cyclic analogues of cyclolinopeptide A(CLA), in which the Phe residues were substituted by the aromatic D-residues (D-Phe, D-Tyr, D-Trp) or by the L-Trp residue, was synthesized by SPPS method. The peptides were tested for their influence on humoral and cellular immune response in mice. Most of the analogues show some immunosuppressive activity similar to that of CLA. High biological activity was observed for the cyclic peptides modified in position 9, especially [D-Phe9]CLA. This corresponds well with the peptide CD spectrum, which shows that the backbone conformation of this analogue resembles most the conformation of CLA.

Original languageEnglish (US)
Pages (from-to)1401-1412
Number of pages12
JournalPolish Journal of Chemistry
Issue number10
StatePublished - Oct 1997
Externally publishedYes


  • Circular dichroism of peptides
  • Cyclolinopeptide A
  • Immunosuppression

ASJC Scopus subject areas

  • Chemistry(all)

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