A series of nine linear and nine cyclic analogues of cyclolinopeptide A(CLA), in which the Phe residues were substituted by the aromatic D-residues (D-Phe, D-Tyr, D-Trp) or by the L-Trp residue, was synthesized by SPPS method. The peptides were tested for their influence on humoral and cellular immune response in mice. Most of the analogues show some immunosuppressive activity similar to that of CLA. High biological activity was observed for the cyclic peptides modified in position 9, especially [D-Phe9]CLA. This corresponds well with the peptide CD spectrum, which shows that the backbone conformation of this analogue resembles most the conformation of CLA.
|Original language||English (US)|
|Number of pages||12|
|Journal||Polish Journal of Chemistry|
|State||Published - Oct 1997|
- Circular dichroism of peptides
- Cyclolinopeptide A
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