The Cryptococcus neoformans genome sequencing project

Joseph Heitman, Arturo Casadevall, Jennifer K. Lodge, John R. Perfect

Research output: Contribution to journalArticle

Abstract

Cryptococcus neoformans is a basidiomycete that can cause life-threatening meningoencephalitis in patients with and without impaired immune function. Cryptococcosis is usually an opportunistic infection in patients with compromised immunity as a consequence of HIV-1 infection, steroid administration, cancer chemotherapy, sarcoidosis, diabetes, or inherited immune system defects. This pathogenic yeast has a defined sexual cycle, which allows classical genetic analysis. Molecular biology approaches, including transformation and gene disruption by homologous recombination, and animal models for studies of virulence are both well developed. Recently an international consortium convened to begin the C. neoformans genome sequencing project, and we review here background and arguments for this project. We also discuss the importance of this project to the biology and virulence of this organism in particular, and to virulence in general.

Original languageEnglish (US)
Pages (from-to)1-7
Number of pages7
JournalMycopathologia
Volume148
Issue number1
DOIs
StatePublished - 1999
Externally publishedYes

Fingerprint

Cryptococcus neoformans
Virulence
virulence
Genome
genome
Cryptococcosis
Basidiomycota
Meningoencephalitis
meningoencephalitis
Homologous Recombination
homologous recombination
Opportunistic Infections
gene targeting
Sarcoidosis
Human immunodeficiency virus 1
infection
molecular biology
drug therapy
HIV Infections
steroids

Keywords

  • Basidiomycete
  • Fungal pathogen
  • Genomic sequence
  • Meningitis
  • Mycology

ASJC Scopus subject areas

  • Agricultural and Biological Sciences (miscellaneous)
  • Plant Science

Cite this

The Cryptococcus neoformans genome sequencing project. / Heitman, Joseph; Casadevall, Arturo; Lodge, Jennifer K.; Perfect, John R.

In: Mycopathologia, Vol. 148, No. 1, 1999, p. 1-7.

Research output: Contribution to journalArticle

Heitman, Joseph ; Casadevall, Arturo ; Lodge, Jennifer K. ; Perfect, John R. / The Cryptococcus neoformans genome sequencing project. In: Mycopathologia. 1999 ; Vol. 148, No. 1. pp. 1-7.
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