The course of neurofibromatosis type 1 on immunosuppression after lung transplantation: Report of 2 cases

Christian A. Merlo, Sean M. Studer, John V. Conte, Stephen C. Yang, Joshua Sonnett, Jonathan B. Orens

Research output: Contribution to journalArticlepeer-review

Abstract

We describe 2 patients with neurofibromatosis type 1 (NF1) who underwent lung transplantation. Case 1 reports a patient with NF1 with no complications 5 years after bilateral lung transplantation. Case 2 details a patient with NF1 diagnosed with both post-transplant lymphoproliferative disorder (PTLD) and massive intra-abdominal sarcoma consistent with a malignant nerve sheath tumor 9 months after lung transplantation. There was no clinical evidence of sarcoma preceding or immediately following lung transplant as demonstrated by a normal abdominal sonogram 3 months post-transplantation. Although an increased risk for cancer has been documented in NF1, the rapid malignant degeneration of a neurofibroma following transplantation raises concern about immunosuppression and transplantation candidacy among individuals with NF1.

Original languageEnglish (US)
Pages (from-to)774-776
Number of pages3
JournalJournal of Heart and Lung Transplantation
Volume23
Issue number6
DOIs
StatePublished - Jun 1 2004

ASJC Scopus subject areas

  • Surgery
  • Pulmonary and Respiratory Medicine
  • Cardiology and Cardiovascular Medicine
  • Transplantation

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