The corticotropin-releasing hormone stimulation test in chronic schizophrenia

A. Roy, D. Pickar, A. Doran, O. Wolkowitz, W. Gallucci, G. Chrousos, P. Gold

Research output: Contribution to journalArticle

Abstract

During a drug-free period a group of schizophrenic subjects (N = 9) showed normal mean basal plasma ACTH and cortisol levels in association with normal plasma ACTH and cortisol responses to an infusion of corticotropin-releasing hormone (CRH). Administration of fluphenazine had no effect on basal ACTH and cortisol levels or their responses to CRH (N = 8). These data differ from those previously reported in depressed patients, who showed elevated basal cortisol values in association with a blunted ACTH response to CRH, and add to a growing body of literature which suggests that hypothalamic-pituitary-adrenal regulation is less disturbed in schizophrenia than in depression.

Original languageEnglish (US)
Pages (from-to)1393-1397
Number of pages5
JournalAmerican Journal of Psychiatry
Volume143
Issue number11
StatePublished - 1986
Externally publishedYes

Fingerprint

Corticotropin-Releasing Hormone
Adrenocorticotropic Hormone
Hydrocortisone
Schizophrenia
Fluphenazine
Depression
Pharmaceutical Preparations

ASJC Scopus subject areas

  • Psychiatry and Mental health

Cite this

Roy, A., Pickar, D., Doran, A., Wolkowitz, O., Gallucci, W., Chrousos, G., & Gold, P. (1986). The corticotropin-releasing hormone stimulation test in chronic schizophrenia. American Journal of Psychiatry, 143(11), 1393-1397.

The corticotropin-releasing hormone stimulation test in chronic schizophrenia. / Roy, A.; Pickar, D.; Doran, A.; Wolkowitz, O.; Gallucci, W.; Chrousos, G.; Gold, P.

In: American Journal of Psychiatry, Vol. 143, No. 11, 1986, p. 1393-1397.

Research output: Contribution to journalArticle

Roy, A, Pickar, D, Doran, A, Wolkowitz, O, Gallucci, W, Chrousos, G & Gold, P 1986, 'The corticotropin-releasing hormone stimulation test in chronic schizophrenia', American Journal of Psychiatry, vol. 143, no. 11, pp. 1393-1397.
Roy A, Pickar D, Doran A, Wolkowitz O, Gallucci W, Chrousos G et al. The corticotropin-releasing hormone stimulation test in chronic schizophrenia. American Journal of Psychiatry. 1986;143(11):1393-1397.
Roy, A. ; Pickar, D. ; Doran, A. ; Wolkowitz, O. ; Gallucci, W. ; Chrousos, G. ; Gold, P. / The corticotropin-releasing hormone stimulation test in chronic schizophrenia. In: American Journal of Psychiatry. 1986 ; Vol. 143, No. 11. pp. 1393-1397.
@article{befb2fbebe89453ca6d6b8a199393b55,
title = "The corticotropin-releasing hormone stimulation test in chronic schizophrenia",
abstract = "During a drug-free period a group of schizophrenic subjects (N = 9) showed normal mean basal plasma ACTH and cortisol levels in association with normal plasma ACTH and cortisol responses to an infusion of corticotropin-releasing hormone (CRH). Administration of fluphenazine had no effect on basal ACTH and cortisol levels or their responses to CRH (N = 8). These data differ from those previously reported in depressed patients, who showed elevated basal cortisol values in association with a blunted ACTH response to CRH, and add to a growing body of literature which suggests that hypothalamic-pituitary-adrenal regulation is less disturbed in schizophrenia than in depression.",
author = "A. Roy and D. Pickar and A. Doran and O. Wolkowitz and W. Gallucci and G. Chrousos and P. Gold",
year = "1986",
language = "English (US)",
volume = "143",
pages = "1393--1397",
journal = "American Journal of Psychiatry",
issn = "0002-953X",
publisher = "American Psychiatric Association",
number = "11",

}

TY - JOUR

T1 - The corticotropin-releasing hormone stimulation test in chronic schizophrenia

AU - Roy, A.

AU - Pickar, D.

AU - Doran, A.

AU - Wolkowitz, O.

AU - Gallucci, W.

AU - Chrousos, G.

AU - Gold, P.

PY - 1986

Y1 - 1986

N2 - During a drug-free period a group of schizophrenic subjects (N = 9) showed normal mean basal plasma ACTH and cortisol levels in association with normal plasma ACTH and cortisol responses to an infusion of corticotropin-releasing hormone (CRH). Administration of fluphenazine had no effect on basal ACTH and cortisol levels or their responses to CRH (N = 8). These data differ from those previously reported in depressed patients, who showed elevated basal cortisol values in association with a blunted ACTH response to CRH, and add to a growing body of literature which suggests that hypothalamic-pituitary-adrenal regulation is less disturbed in schizophrenia than in depression.

AB - During a drug-free period a group of schizophrenic subjects (N = 9) showed normal mean basal plasma ACTH and cortisol levels in association with normal plasma ACTH and cortisol responses to an infusion of corticotropin-releasing hormone (CRH). Administration of fluphenazine had no effect on basal ACTH and cortisol levels or their responses to CRH (N = 8). These data differ from those previously reported in depressed patients, who showed elevated basal cortisol values in association with a blunted ACTH response to CRH, and add to a growing body of literature which suggests that hypothalamic-pituitary-adrenal regulation is less disturbed in schizophrenia than in depression.

UR - http://www.scopus.com/inward/record.url?scp=0023002798&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0023002798&partnerID=8YFLogxK

M3 - Article

VL - 143

SP - 1393

EP - 1397

JO - American Journal of Psychiatry

JF - American Journal of Psychiatry

SN - 0002-953X

IS - 11

ER -