The correlation of pretreatment transurethral resection of prostatic cancer with tumor dissemination and disease‐free survival: A univariate and multivariate analysis

A multivariate Cox's hazard function analysis was performed on the prognostic variables selected from 240 patients with localized carcinoma of the prostate who received external beam radiotherapy to analyze the association between the method of biopsy and disease‐free survival. The patients received 4500 cGy to the pelvis followed by a 2‐week treatment rest and then an additional 2000 cGy to the reduced prostatic volume. Median follow‐up was 4 years (range, 1–9 years). The 5‐year actuarial local control rate was 91%. There was no difference in local control relative to the method of biopsy (needle biopsy or transurethral resection of the prostate [TURP]). The 5‐year actuarial risks of metastases were 28% and 48% for the needle biopsy and TURP groups, respectively (P < 0.01). The 5‐year disease‐free survival for the needle biopsy and TURP groups were 55% and 42%, respectively (P < 0.05). This difference maintained statistical significance for Stage C and Grade III tumors. A multivariate analysis demonstrated that “method of biopsy” was the third most powerful variable after serum acid phosphatase level and modified Broders' grade in predicting disease‐free survival. Patients who had TURP had an almost twofold higher relative risk of disease progression than those who had needle biopsy. This study established the correlation of the method of biopsy with a lower probability of disease‐free survival over and above the information obtained from the clinical stage, histologic grade, presence or absence of symptoms of obstruction, acid phosphatase level, and lymph node status. The association of TURP with tumor dissemination is discussed with reference to the mechanism of metastasis formation and prevention.