TY - JOUR
T1 - The correlation between clinical, nuclear and histologic findings in a patient with Von Recklinghausen's disease
AU - Brinkman, Justus Martijn
AU - Bron, Johannes L.
AU - Wuisman, Paul I.J.M.
AU - van Diest, Paul J.
AU - Comans, Emile F.I.
AU - Molthoff, Carla F.M.
PY - 2007/11/12
Y1 - 2007/11/12
N2 - Background: Malignant peripheral nerve sheath tumours (MPNST) are known to develop in patients with Neurofibromatosis type I (NF1) resulting in a decreased overall survival. The association between NF1 and the development of such MPNST has been investigated in detail. The biological behaviour however of multiple disseminated neurofibromas in patients with NF1 and the risk factors for malignant transformation remain unknown. Clinical signs are unreliable and additional imaging techniques are therefore required. Of such, positron emission tomography using [18F]-2-fluoro-2-deoxy-D-glucose (18FDG PET) is used to detect malignant changes in neurofibromas. Case presentation: A case is presented of a patient suffering from NF1 with clinical signs of malignant change and accumulation of 18FDG in multiple neurofibromas. Histopathological examination of 20 lesions however, did not reveal any malignant features. There was no statistically significant relation between 18FDG accumulation and malignant change, but rather with pain, size and growth. Conclusion: This case adds to the knowledge of the diverse biological behaviour of neurofibromas in patients with NF1
AB - Background: Malignant peripheral nerve sheath tumours (MPNST) are known to develop in patients with Neurofibromatosis type I (NF1) resulting in a decreased overall survival. The association between NF1 and the development of such MPNST has been investigated in detail. The biological behaviour however of multiple disseminated neurofibromas in patients with NF1 and the risk factors for malignant transformation remain unknown. Clinical signs are unreliable and additional imaging techniques are therefore required. Of such, positron emission tomography using [18F]-2-fluoro-2-deoxy-D-glucose (18FDG PET) is used to detect malignant changes in neurofibromas. Case presentation: A case is presented of a patient suffering from NF1 with clinical signs of malignant change and accumulation of 18FDG in multiple neurofibromas. Histopathological examination of 20 lesions however, did not reveal any malignant features. There was no statistically significant relation between 18FDG accumulation and malignant change, but rather with pain, size and growth. Conclusion: This case adds to the knowledge of the diverse biological behaviour of neurofibromas in patients with NF1
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U2 - 10.1186/1477-7819-5-130
DO - 10.1186/1477-7819-5-130
M3 - Article
C2 - 17997819
AN - SCOPUS:38049128728
SN - 1477-7819
VL - 5
JO - World Journal of Surgical Oncology
JF - World Journal of Surgical Oncology
M1 - 130
ER -