The coronavirus E protein: Assembly and beyond

Travis R. Ruch, Carolyn E Machamer

Research output: Contribution to journalArticle

Abstract

The coronavirus E protein is a small membrane protein that has an important role in the assembly of virions. Recent studies have indicated that the E protein has functions during infection beyond assembly, including in virus egress and in the host stress response. Additionally, the E protein has ion channel activity, interacts with host proteins, and may have multiple membrane topologies. The goal of this review is to highlight the properties and functions of the E protein, and speculate on how they may be related.

Original languageEnglish (US)
Pages (from-to)363-382
Number of pages20
JournalViruses
Volume4
Issue number3
DOIs
StatePublished - Mar 2012

Fingerprint

Coronavirus
Proteins
Virus Release
Ion Channels
Virion
Membrane Proteins
Membranes
Infection

Keywords

  • Coronavirus assembly
  • Envelope protein
  • Golgi complex
  • Ion channel
  • Membrane protein topology

ASJC Scopus subject areas

  • Infectious Diseases
  • Virology

Cite this

The coronavirus E protein : Assembly and beyond. / Ruch, Travis R.; Machamer, Carolyn E.

In: Viruses, Vol. 4, No. 3, 03.2012, p. 363-382.

Research output: Contribution to journalArticle

Ruch, Travis R. ; Machamer, Carolyn E. / The coronavirus E protein : Assembly and beyond. In: Viruses. 2012 ; Vol. 4, No. 3. pp. 363-382.
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