The COPD Assessment Test: Can It Discriminate Across COPD Subpopulations?

Nisha Gupta, Lancelot Pinto, Andrea Benedetti, Pei Zhi Li, Wan C. Tan, Shawn D. Aaron, Kenneth R. Chapman, J. Mark FitzGerald, Paul Hernandez, Darcy D. Marciniuk, François Maltais, Denis E. O'Donnell, Don Sin, Brandie L. Walker, Jean Bourbeau, Jean Bourbeau, Wan C. Tan, J. Mark FitzGerald, D. D. Sin, D. D. MarciniukD. E. O'Donnell, Paul Hernandez, Kenneth R. Chapman, Robert Cowie, Shawn Aaron, F. Maltais, Jonathon Samet, Milo Puhan, Qutayba Hamid, James C. Hogg, Jean Bourbeau, Carole Baglole, Carole Jabet, Palmina Mancino, Yvan Fortier, Wan C. Tan, Don Sin, Sheena Tam, Jeremy Road, Joe Comeau, Adrian Png, Harvey Coxson, Miranda Kirby, Jonathon Leipsic, Cameron Hague, Mohsen Sadatsafavi, Teresa To, Andrea Gershon, Wan C. Tan, Harvey Coxson, Jean Bourbeau, Pei Zhi Li, Jean Francois Duquette, Yvan Fortier, Andrea Benedetti, Denis Jensen, Denis O'Donnell, Wan C. Tan, Christine Lo, Sarah Cheng, Cindy Fung, Nancy Haynes, Junior Chuang, Liyun Zheng, Jean Bourbeau, Palmina Mancino, David Latreille, Jacinthe Baril, Laura Labonte, Kenneth Chapman, Patricia McClean, Nadeen Audisho, Robert Cowie, Ann Cowie, Curtis Dumonceaux, Lisette Machado, Paul Hernandez, Scott Fulton, Kristen Osterling, Shawn Aaron, Kathy Vandemheen, Gay Pratt, Amanda Bergeron, Denis O'Donnell, Matthew McNeil, Kate Whelan, Francois Maltais, Cynthia Brouillard, Darcy Marciniuk, Ron Clemens, Janet Baran

Research output: Contribution to journalArticlepeer-review

Abstract

Background The COPD Assessment Test (CAT) is a valid disease-specific questionnaire measuring health status. However, knowledge concerning its use regarding patient and disease characteristics remains limited. Our main objective was to assess the degree to which the CAT score varies and can discriminate between specific patient population groups. Methods The Canadian Cohort Obstructive Lung Disease (CanCOLD) is a random-sampled, population-based, multicenter, prospective cohort that includes subjects with COPD (Global Initiative for Chronic Obstructive Lung Disease [GOLD] classifications 1 to 3). The CAT questionnaire was administered at three visits (baseline, 1.5 years, and 3 years). The CAT total score was determined for sex, age groups, smoking status, GOLD classification, exacerbations, and comorbidities. Results A total of 716 subjects with COPD were included in the analysis. The majority of subjects (72.5%) were not previously diagnosed with COPD. The mean FEV1/FVC ratio was 61.1 ± 8.1%, with a mean FEV1 % predicted of 82.3 ± 19.3%. The mean CAT scores were 5.8 ± 5.0, 9.6 ± 6.7, and 16.1 ± 10.0 for GOLD 1, 2, and 3+ classifications, respectively. Higher CAT scores were observed in women, current smokers, ever-smokers, and subjects with a previous diagnosis of COPD. The CAT was also able to distinguish between subjects who experience exacerbations vs those who had no exacerbation. Conclusions These results suggest that the CAT, originally designed for use in clinically symptomatic patients with COPD, can also be used in individuals with mild airflow obstruction and newly diagnosed COPD. In addition, the CAT was able to discriminate between sexes and subjects who experience frequent and infrequent exacerbations. Trial Registry ClinicalTrials.gov; No.: NCT00920348; Study ID No.: IRO-93326.

Original languageEnglish (US)
Pages (from-to)1069-1079
Number of pages11
JournalChest
Volume150
Issue number5
DOIs
StatePublished - Nov 1 2016
Externally publishedYes

Keywords

  • COPD
  • health-related quality of life
  • patient-reported outcome

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine
  • Critical Care and Intensive Care Medicine
  • Cardiology and Cardiovascular Medicine

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