The control of gastric emptying

Paul R. McHugh

doi:10.1016/0165-1838(83)90143-1

The control of gastric emptying

Paul R. McHugh

School of Medicine

Research output: Contribution to journal › Article › peer-review

32 Scopus citations

Abstract

The control of gastric emptying has been restudied. Methods used are described. It was found that in the alert unanesthetized monkey saline is emptied from the stomach at a rate that is volume-dependent; an exponential curve results since higher volumes provoke more rapid emptying and lower volumes slower emptying. For glucose test meals emptying is quite linear; also emptying is slower and progressively slower with progressive increases in glucose concentration. There is, however, an early rapid phase of gastric emptying that converts to a slower, more linear pattern. Calories rather than osmoles appear to control emptying. Glucose in the pyloris has an inhibitory effect in gastric emptying. A theory of control is discussed. The control of gastric emptying also relates to the control of feeding.

Original language	English (US)
Pages (from-to)	221-231
Number of pages	11
Journal	Journal of the Autonomic Nervous System
Volume	9
Issue number	1
DOIs	https://doi.org/10.1016/0165-1838(83)90143-1
State	Published - Oct 1983

Keywords

calorie intake
control theory
gastric emptying
inhibitory feedback
pyloric control
steady state

ASJC Scopus subject areas

Neuroscience(all)
Physiology
Clinical Neurology

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10.1016/0165-1838(83)90143-1

Cite this

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abstract = "The control of gastric emptying has been restudied. Methods used are described. It was found that in the alert unanesthetized monkey saline is emptied from the stomach at a rate that is volume-dependent; an exponential curve results since higher volumes provoke more rapid emptying and lower volumes slower emptying. For glucose test meals emptying is quite linear; also emptying is slower and progressively slower with progressive increases in glucose concentration. There is, however, an early rapid phase of gastric emptying that converts to a slower, more linear pattern. Calories rather than osmoles appear to control emptying. Glucose in the pyloris has an inhibitory effect in gastric emptying. A theory of control is discussed. The control of gastric emptying also relates to the control of feeding.",

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N2 - The control of gastric emptying has been restudied. Methods used are described. It was found that in the alert unanesthetized monkey saline is emptied from the stomach at a rate that is volume-dependent; an exponential curve results since higher volumes provoke more rapid emptying and lower volumes slower emptying. For glucose test meals emptying is quite linear; also emptying is slower and progressively slower with progressive increases in glucose concentration. There is, however, an early rapid phase of gastric emptying that converts to a slower, more linear pattern. Calories rather than osmoles appear to control emptying. Glucose in the pyloris has an inhibitory effect in gastric emptying. A theory of control is discussed. The control of gastric emptying also relates to the control of feeding.

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The control of gastric emptying

Abstract

Keywords

ASJC Scopus subject areas

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