The Contribution of Endothelial Activation and Injury to End-Organ Toxicity following Allogeneic Hematopoietic Stem Cell Transplantation

Kenneth R Cooke, Anne Jannin, Vincent Ho

Research output: Contribution to journalArticle

Abstract

Over the last 25 years, allogeneic hematopoietic stem cell transplantation (HSCT) has been used increasingly as a curative treatment option for patients with hematologic and neoplastic diseases. Despite major advances in transplant immunology and improvements in supportive and critical care medicine, HSCT is still plagued by several life-threatening complications. As such, the establishment of effective therapeutic options for these complications will be crucial as increasing numbers of high-risk transplants are performed each year. This brief review will discuss the contribution of vascular endothelial cell activation and injury to inflammation and end-organ toxicity that occurs following allogeneic HSCT, and will highlight translational research efforts that have paved the way to the development of novel strategies to treat and prevent disease. Finally, we will discuss in detail the clinical manifestations and challenges encompassed by the syndrome of thrombotic microangiopathy following HSCT.

Original languageEnglish (US)
Pages (from-to)23-32
Number of pages10
JournalBiology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation
Volume14
Issue number1 SUPPL.
DOIs
Publication statusPublished - Jan 2008
Externally publishedYes

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Keywords

  • Cytokines
  • Endothelial cell
  • Graft-versus-host disease
  • Hematopoietic stem cell transplantation
  • Idiopathic pneumonia syndrome
  • Inflammation
  • Microvasculature
  • Thrombotic microangiopathy
  • Tumor necrosis factor-alpha
  • Veno-occlusive disease

ASJC Scopus subject areas

  • Transplantation

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