The connectivity map: Using gene-expression signatures to connect small molecules, genes, and disease

Justin Lamb; Emily D. Crawford; David Peck; Joshua W. Modell; Irene C. Blat; Matthew J. Wrobel; Jim Lerner; Jean Philippe Brunet; Aravind Subramanian; Kenneth N. Ross; Michael Reich; Haley Hieronymus; Guo Wei; Scott A. Armstrong; Stephen J. Haggarty; Paul A. Clemons; Ru Wei; Steven A. Carr; Eric S. Lander; Todd R. Golub

doi:10.1126/science.1132939

The connectivity map: Using gene-expression signatures to connect small molecules, genes, and disease

Justin Lamb, Emily D. Crawford, David Peck, Joshua W. Modell, Irene C. Blat, Matthew J. Wrobel, Jim Lerner, Jean Philippe Brunet, Aravind Subramanian, Kenneth N. Ross, Michael Reich, Haley Hieronymus, Guo Wei, Scott A. Armstrong, Stephen J. Haggarty, Paul A. Clemons, Ru Wei, Steven A. Carr, Eric S. Lander, Todd R. Golub

Research output: Contribution to journal › Article › peer-review

2914 Scopus citations

Abstract

To pursue a systematic approach to the discovery of functional connections among diseases, genetic perturbation, and drug action, we have created the first installment of a reference collection of gene-expression profiles from cultured human cells treated with bioactive small molecules, together with pattern-matching software to mine these data. We demonstrate that this "Connectivity Map" resource can be used to find connections among small molecules sharing a mechanism of action, chemicals and physiological processes, and diseases and drugs. These results indicate the feasibility of the approach and suggest the value of a large-scale community Connectivity Map project.

Original language	English (US)
Pages (from-to)	1929-1935
Number of pages	7
Journal	Science
Volume	313
Issue number	5795
DOIs	https://doi.org/10.1126/science.1132939
State	Published - Sep 29 2006
Externally published	Yes

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Lamb, J., Crawford, E. D., Peck, D., Modell, J. W., Blat, I. C., Wrobel, M. J., Lerner, J., Brunet, J. P., Subramanian, A., Ross, K. N., Reich, M., Hieronymus, H., Wei, G., Armstrong, S. A., Haggarty, S. J., Clemons, P. A., Wei, R., Carr, S. A., Lander, E. S., & Golub, T. R. (2006). The connectivity map: Using gene-expression signatures to connect small molecules, genes, and disease. Science, 313(5795), 1929-1935. https://doi.org/10.1126/science.1132939

Lamb, J, Crawford, ED, Peck, D, Modell, JW, Blat, IC, Wrobel, MJ, Lerner, J, Brunet, JP, Subramanian, A, Ross, KN, Reich, M, Hieronymus, H, Wei, G, Armstrong, SA, Haggarty, SJ, Clemons, PA, Wei, R, Carr, SA, Lander, ES & Golub, TR 2006, 'The connectivity map: Using gene-expression signatures to connect small molecules, genes, and disease', Science, vol. 313, no. 5795, pp. 1929-1935. https://doi.org/10.1126/science.1132939

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abstract = "To pursue a systematic approach to the discovery of functional connections among diseases, genetic perturbation, and drug action, we have created the first installment of a reference collection of gene-expression profiles from cultured human cells treated with bioactive small molecules, together with pattern-matching software to mine these data. We demonstrate that this {"}Connectivity Map{"} resource can be used to find connections among small molecules sharing a mechanism of action, chemicals and physiological processes, and diseases and drugs. These results indicate the feasibility of the approach and suggest the value of a large-scale community Connectivity Map project.",

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AU - Wrobel, Matthew J.

AU - Lerner, Jim

AU - Brunet, Jean Philippe

AU - Subramanian, Aravind

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AU - Haggarty, Stephen J.

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The connectivity map: Using gene-expression signatures to connect small molecules, genes, and disease

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