TY - JOUR
T1 - The complete nucleotide sequence of the Crossostoma lacustre mitochondrial genome
T2 - Conservation and variations among vertebrates
AU - Tzeng, Chyng shyan
AU - Hui, Cho fat
AU - Shen, Shih chieh
AU - Huang, P. C.
N1 - Funding Information:
We thank Dr. Igor Dawid for a plasmid clone of Xenopus laevis mtDNA used for homology assays in the early screening for clones used in this study. We are grateful to Dr. L.-Y.Lin, Dr. J.-R.Wu, Mrs. Y.-J.Chu and Dr. H.-C.Chi for their helpful discussions. We thank Dr. M.-T.Tam for his assistance in oligonucleotide synthesis, Mr. Cicero Chen for computer analyses. This work was supported by grants from Academia Sinica, and National Science Council (Grant No. NSC80-0209-B-002-05), Taiwan, Republic of China.
PY - 1992/9/25
Y1 - 1992/9/25
N2 - The complete mitochondrial (mt) genome of Crossostoma lacustre, a freshwater bach from mountain stream of Taiwan, has been cloned and sequenced. This fish mt genome, consisting of 16558 base-pairs, encodes genes for 13 proteins, two rRNAs, and 22 rRNAs, in addition to a regulatory sequence for replication and transcription (D-loop), is similar to those of the other vertebrates in both the order and orientation of these genes. The protein-coding and ribosomal RNA genes are highly homologous both In size and composition, to their counterparts in mammals, birds, amphibians, and invertebrates, and using essentially the same set of codons, including both the initiation and termination signals, and the tRNAs. Differences do exist, however, in the lengths and sequences of the D-loop regions, and in space between genes, which account for the variations in total lengths of the genomes. Our observations provide evidence for the first time for the conservation of genetic information in the fish mitochondrial genome, especially among the vertebrates.
AB - The complete mitochondrial (mt) genome of Crossostoma lacustre, a freshwater bach from mountain stream of Taiwan, has been cloned and sequenced. This fish mt genome, consisting of 16558 base-pairs, encodes genes for 13 proteins, two rRNAs, and 22 rRNAs, in addition to a regulatory sequence for replication and transcription (D-loop), is similar to those of the other vertebrates in both the order and orientation of these genes. The protein-coding and ribosomal RNA genes are highly homologous both In size and composition, to their counterparts in mammals, birds, amphibians, and invertebrates, and using essentially the same set of codons, including both the initiation and termination signals, and the tRNAs. Differences do exist, however, in the lengths and sequences of the D-loop regions, and in space between genes, which account for the variations in total lengths of the genomes. Our observations provide evidence for the first time for the conservation of genetic information in the fish mitochondrial genome, especially among the vertebrates.
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U2 - 10.1093/nar/20.18.4853
DO - 10.1093/nar/20.18.4853
M3 - Article
C2 - 1408800
AN - SCOPUS:0026670894
SN - 0305-1048
VL - 20
SP - 4853
EP - 4858
JO - Nucleic acids research
JF - Nucleic acids research
IS - 18
ER -