The combined effect of age and basal follicle-stimulating hormone on the cost of a live birth at assisted reproductive technology

Melinda B. Henne, Barbara J. Stegmann, Adrienne B. Neithardt, William H. Catherino, Alicia Y. Armstrong, Tzu Cheg Kao, James H. Segars

Research output: Contribution to journalArticlepeer-review

Abstract

Objective: To predict the cost of a delivery following assisted reproductive technologies (ART). Design: Cost analysis based on retrospective chart analysis. Setting: University-based ART program. Patient(s): Women aged ≥26 and ≤42 years with FSH levels ≤12 IU/L on day 3 undergoing a first cycle of fresh, nondonor ART. Intervention(s): Logit regression using a fractional polynomial model of age and basal FSH was used to estimate the probability of a live birth. Cost analysis was applied to the resulting prediction. Main Outcome Measure(s): The predicted probability of a live birth following ART based on a woman's age and FSH and the associated cost of a live birth. Result(s): Analysis of 1,238 first ART cycles produced a prediction model for live birth rates following ART incorporating both age and FSH. A cost analysis based upon combination of age and FSH revealed the cost of a live birth exceeded $100,000 when the probability of a live birth fell below 15% and the cost rose exponentially at lower probabilities of live birth. Conclusions(s): Based upon a woman's age and FSH and expected cost for a live birth using ART may be calculated. At live birth rates <5%, the cost of ART is high and greatly exceeds the cost of donor cycles. This information is vital for patient counseling.

Original languageEnglish (US)
Pages (from-to)104-110
Number of pages7
JournalFertility and sterility
Volume89
Issue number1
DOIs
StatePublished - Jan 2008
Externally publishedYes

Keywords

  • ART
  • FSH
  • IVF
  • In vitro fertilization
  • age
  • assisted reproduction
  • cost analysis

ASJC Scopus subject areas

  • Reproductive Medicine
  • Obstetrics and Gynecology

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