The Combined Effect of 5-Fluorocytosine and Amphotericin B in the Therapy of Murine Cryptococcosis

Edward R. Block, John E. Bennett

Research output: Contribution to journalArticlepeer-review

Abstract

5-Fluorocytosine and amphotericin B were demonstrated to be at least additive in the therapy of murine cryptococcosis. The mechanism for this effect is not known. However, AmB seemed to inhibit the in vivo development of 5-FC resistance among C. neoformans in our model. These results raise the possibility that combined-drug therapy might reduce AmB toxicity and/or the appearance of 5-FC resistant cryptococci without compromising therapeutic efficacy in cryptococcal disease. We are greatly indebted to Dr. David W. Alling for constant and invaluable advice on the mathematical problems of experimental design and data analysis.

Original languageEnglish (US)
Pages (from-to)476-480
Number of pages5
JournalProceedings of the Society for Experimental Biology and Medicine
Volume142
Issue number2
DOIs
StatePublished - Feb 1973

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

Fingerprint Dive into the research topics of 'The Combined Effect of 5-Fluorocytosine and Amphotericin B in the Therapy of Murine Cryptococcosis'. Together they form a unique fingerprint.

Cite this