The Combination of Platelet-Enriched Autologous Plasma with Bovine Collagen and Thrombin Decreases the Need for Multiple Blood Transfusions in Trauma Patients with Retroperitoneal Bleeding

Grant Bochicchio, James Dunne, Kelly Bochicchio, Thomas Scalea

Research output: Contribution to journalArticle

Abstract

Objectives: Bleeding from blunt and penetrating retroperitoneal injuries during operative exploration are often difficult to control surgically and can be associated with significant blood loss. Our goals were to evaluate and compare the efficacy of a topical autologous platelet-enriched plasma combined with bovine collagen and thrombin (PCT) to Gelfoam/ thrombin (G/T) in relation to hemostatic control/blood transfusion (BTx) requirements and subsequent outcome. Methods: Prospective data were collected on all patients who underwent operative exploration for retroperitoneal injuries in which either PCT or G/T was applied with or without packing over a 2.5-year period. Patients were stratified by age, gender, mechanism of injury, preoperative international normalized ratio, pH, hematocrit, intraoperative blood loss, and BTx requirements. Subsequent BTx requirements were calculated within 48 hours of the surgical procedure. Outcome was measured by intensive care unit and hospital length of stay and mortality. Results: A total of 78 patients met study criteria. Patients who received G/T had a significantly greater number of early postoperative transfusions (p <0.001) and a longer hospital (p <0.001) and intensive care unit length of stay (p <0.007). There was no difference in mortality. Conclusion: PCT is a rapidly available topical hemostat that is associated with a significant decrease in the need for postoperative blood transfusions and intensive care unit and hospital length of stay. A randomized prospective trial to confirm these results is warranted.

Original languageEnglish (US)
Pages (from-to)76-79
Number of pages4
JournalJournal of Trauma - Injury, Infection and Critical Care
Volume56
Issue number1
StatePublished - Jan 2004
Externally publishedYes

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Thrombin
Blood Transfusion
Absorbable Gelatin Sponge
Length of Stay
Collagen
Blood Platelets
Hemorrhage
Wounds and Injuries
Intensive Care Units
International Normalized Ratio
Hemostatics
Hospital Mortality
Hematocrit
Mortality

Keywords

  • Autologous plasma
  • Bovine collagen
  • Retroperitoneal bleeding
  • Thrombin

ASJC Scopus subject areas

  • Surgery

Cite this

The Combination of Platelet-Enriched Autologous Plasma with Bovine Collagen and Thrombin Decreases the Need for Multiple Blood Transfusions in Trauma Patients with Retroperitoneal Bleeding. / Bochicchio, Grant; Dunne, James; Bochicchio, Kelly; Scalea, Thomas.

In: Journal of Trauma - Injury, Infection and Critical Care, Vol. 56, No. 1, 01.2004, p. 76-79.

Research output: Contribution to journalArticle

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