The Collaborative Ocular Tuberculosis Study (COTS) Consensus (CON) Group Meeting Proceedings

Rupesh Agrawal, Ilaria Testi, Sarakshi Mahajan, Yew Sen Yuen, Aniruddha Agarwal, Andres Rousselot, Dhananjay Raje, Dinesh Visva Gunasekeran, Onn Min Kon, Talin Barisani-Asenbauer, John H. Kempen, Amod Gupta, Douglas A. Jabs, Justine R. Smith, Bahram Bodaghi, Manfred Zierhut, Marc DeSmet, Peter Mc Cluskey, Mamta Agarwal, Manisha AgarwalKanika Aggarwal, Mukesh Agrawal, Hassan Al-Dhibi, Sofia Androudi, Fatma Asyari, Manohar Babu Balasundaram, Kalpana Babu Murthy, Edoardo Baglivo, Alay Banker, Reema Bansal, Soumyava Basu, Digamber Behera, Jyotirmay Biswas, Ester Carreño, Laure Caspers, Soon Phaik Chee, Romi Chhabra, Luca Cimino, Luz Elena Concha del Rio, Emmett T. Cunningham, Andrè Luiz Land Curi, Dipankar Das, Ekaterina Denisova, Alastair K. Denniston, Marie Hélène Errera, Alejandro Fonollosa, Amala George, Debra A. Goldstein, Yan Guex Crosier, Avinash Gurbaxani, Alessandro Invernizzi, Hazlita M. Isa, Shah Md. Islam, Nicholas Jones, Deeksha Katoch, Moncef Khairallah, Amit Khosla, Michal Kramer, Amitabh Kumar, Atul Kumar, Rina La Distia Nora, Richard Lee, Careen Lowder, Saurabh Luthra, Padmamalini Mahendradas, Dorine Makhoul, Shahana Mazumdar, Salil Mehta, Elisabetta Miserocchi, Manabu Mochizuki, Oli S. Mohamed, Cristina Muccioli, Marion R. Munk, Somasheila Murthy, Shishir Narain, Heloisa Nascimento, Piergiorgio Neri, Myhanh Nguyen, Annabelle A. Okada, Pinar Ozdal, Alan Palestine, Francesco Pichi, S. R. Rathinam, Ariel Schlaen, Shobha Sehgal, H. Nida Sen, Aman Sharma, Kusum Sharma, Samir S. Shoughy, Nirbhai Singh, Ramandeep Singh, Masoud Soheilian, Sudharshan Sridharan, Jennifer E. Thorne, Christoph Tappeiner, Stephen Teoh, Maria Sofia Tognon, Ilknur Tugal-Tutkun, Mudit Tyagi, Harvey Uy, Daniel Vitor Vasconcelos Santos, Natasa Vidovic Valentincic, Mark Westcott, Ryoji Yanai, Bety Yanez Alvarez, Rahman Zahedur, Quan Dong Nguyen, Carlos Pavesio, Vishali Gupta

Research output: Contribution to journalArticle

Abstract

An international, expert led consensus initiative was set up by the Collaborative Ocular Tuberculosis Study (COTS) group to develop systematic, evidence, and experience-based recommendations for the treatment of ocular TB using a modified Delphi technique process. In the first round of Delphi, the group identified clinical scenarios pertinent to ocular TB based on five clinical phenotypes (anterior uveitis, intermediate uveitis, choroiditis, retinal vasculitis, and panuveitis). Using an interactive online questionnaires, guided by background knowledge from published literature, 486 consensus statements for initiating ATT were generated and deliberated amongst 81 global uveitis experts. The median score of five was considered reaching consensus for initiating ATT. The median score of four was tabled for deliberation through Delphi round 2 in a face-to-face meeting. This report describes the methodology adopted and followed through the consensus process, which help elucidate the guidelines for initiating ATT in patients with choroidal TB.

Original languageEnglish (US)
JournalOcular Immunology and Inflammation
DOIs
StateAccepted/In press - 2020

Keywords

  • Antitubercular therapy
  • Collaborative Ocular Tuberculosis Study Consensus (COTS CON)
  • choroiditis
  • consensus guidelines
  • ocular tuberculosis

ASJC Scopus subject areas

  • Immunology and Allergy
  • Ophthalmology

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  • Cite this

    Agrawal, R., Testi, I., Mahajan, S., Yuen, Y. S., Agarwal, A., Rousselot, A., Raje, D., Gunasekeran, D. V., Kon, O. M., Barisani-Asenbauer, T., Kempen, J. H., Gupta, A., Jabs, D. A., Smith, J. R., Bodaghi, B., Zierhut, M., DeSmet, M., Cluskey, P. M., Agarwal, M., ... Gupta, V. (Accepted/In press). The Collaborative Ocular Tuberculosis Study (COTS) Consensus (CON) Group Meeting Proceedings. Ocular Immunology and Inflammation. https://doi.org/10.1080/09273948.2020.1716025