The clinical profile of moderate amblyopia in children younger than 7 years

Michael X Repka, Roy W. Beck, Raymond T. Kraker, Stephen R. Cole, Jonathan M. Holmes, Eileen E. Birch, D. Robbins Tien, William F. Astle, Susan A. Cotter

Research output: Contribution to journalArticle


Objective: To describe the demographic and clinical characteristics of a cohort of children with moderate amblyopia participating in the Amblyopia Treatment Study 1, a randomized trial comparing atropine and patching. Methods: The children enrolled were younger than 7 years and had strabismic, anisometropic, or combined strabismic and anisometropic amblyopia. Visual acuity, measured with a standardized testing protocol using single-surround HOTV optotypes, was 20/40 to 20/100 in the amblyopic eye, with an intereye acuity difference of 3 or more logMAR lines. There were 419 children enrolled, 409 of whom met these criteria and were included in the analyses. Results: The mean age of the 409 children was 5.3 years. The cause of the amblyopia was strabismus in 38%, anisometropia in 37%, and both strabismus and anisometropia in 24%. The mean visual acuity of the amblyopic eyes (approximately 20/60) was similar among the strabismic, anisometropic, and combined groups (P=.24), but visual acuity of the sound eyes was worse in the strabismic group compared with the anisometropic group (P

Original languageEnglish (US)
Pages (from-to)281-287
Number of pages7
JournalArchives of Ophthalmology
Issue number3
StatePublished - 2002
Externally publishedYes


ASJC Scopus subject areas

  • Ophthalmology

Cite this

Repka, M. X., Beck, R. W., Kraker, R. T., Cole, S. R., Holmes, J. M., Birch, E. E., Tien, D. R., Astle, W. F., & Cotter, S. A. (2002). The clinical profile of moderate amblyopia in children younger than 7 years. Archives of Ophthalmology, 120(3), 281-287.