The clinical implications of antitumor immunity in head and neck cancer

Clint T Allen, Nancy P. Judd, Jack D. Bui, Ravindra Uppaluri

Research output: Contribution to journalArticle

Abstract

Recent developments have renewed interest in understanding the interaction between transformed cells and the immune system in the tumor microenvironment. Here, we provide a comprehensive review addressing the basics of tumor immunology in relation to head and neck cancer and the cellular components potentially involved in antitumor immune responses. In addition, we describe the mechanisms by which head and neck cancer cells escape immune-mediated killing and progress to form clinically significant disease. Further, we detail what effects standard anticancer therapies may have on antitumor immune responses and how these responses may be altered by current and investigational immunotherapies. Finally, we discuss future directions that need to be considered in the development of new immunotherapeutics designed to durably alter the immune response in favor of the host.

Original languageEnglish (US)
Pages (from-to)144-157
Number of pages14
JournalLaryngoscope
Volume122
Issue number1
DOIs
StatePublished - Jan 2012
Externally publishedYes

Fingerprint

Head and Neck Neoplasms
Immunity
Tumor Microenvironment
Allergy and Immunology
Immunotherapy
Immune System
Neoplasms
Therapeutics
Direction compound

Keywords

  • head and neck cancer
  • immunotherapy
  • standard therapy
  • Tumor immunity

ASJC Scopus subject areas

  • Otorhinolaryngology

Cite this

The clinical implications of antitumor immunity in head and neck cancer. / Allen, Clint T; Judd, Nancy P.; Bui, Jack D.; Uppaluri, Ravindra.

In: Laryngoscope, Vol. 122, No. 1, 01.2012, p. 144-157.

Research output: Contribution to journalArticle

Allen, Clint T ; Judd, Nancy P. ; Bui, Jack D. ; Uppaluri, Ravindra. / The clinical implications of antitumor immunity in head and neck cancer. In: Laryngoscope. 2012 ; Vol. 122, No. 1. pp. 144-157.
@article{948cde763be54524acd0133b5fa7a1db,
title = "The clinical implications of antitumor immunity in head and neck cancer",
abstract = "Recent developments have renewed interest in understanding the interaction between transformed cells and the immune system in the tumor microenvironment. Here, we provide a comprehensive review addressing the basics of tumor immunology in relation to head and neck cancer and the cellular components potentially involved in antitumor immune responses. In addition, we describe the mechanisms by which head and neck cancer cells escape immune-mediated killing and progress to form clinically significant disease. Further, we detail what effects standard anticancer therapies may have on antitumor immune responses and how these responses may be altered by current and investigational immunotherapies. Finally, we discuss future directions that need to be considered in the development of new immunotherapeutics designed to durably alter the immune response in favor of the host.",
keywords = "head and neck cancer, immunotherapy, standard therapy, Tumor immunity",
author = "Allen, {Clint T} and Judd, {Nancy P.} and Bui, {Jack D.} and Ravindra Uppaluri",
year = "2012",
month = "1",
doi = "10.1002/lary.21913",
language = "English (US)",
volume = "122",
pages = "144--157",
journal = "Laryngoscope",
issn = "0023-852X",
publisher = "John Wiley and Sons Inc.",
number = "1",

}

TY - JOUR

T1 - The clinical implications of antitumor immunity in head and neck cancer

AU - Allen, Clint T

AU - Judd, Nancy P.

AU - Bui, Jack D.

AU - Uppaluri, Ravindra

PY - 2012/1

Y1 - 2012/1

N2 - Recent developments have renewed interest in understanding the interaction between transformed cells and the immune system in the tumor microenvironment. Here, we provide a comprehensive review addressing the basics of tumor immunology in relation to head and neck cancer and the cellular components potentially involved in antitumor immune responses. In addition, we describe the mechanisms by which head and neck cancer cells escape immune-mediated killing and progress to form clinically significant disease. Further, we detail what effects standard anticancer therapies may have on antitumor immune responses and how these responses may be altered by current and investigational immunotherapies. Finally, we discuss future directions that need to be considered in the development of new immunotherapeutics designed to durably alter the immune response in favor of the host.

AB - Recent developments have renewed interest in understanding the interaction between transformed cells and the immune system in the tumor microenvironment. Here, we provide a comprehensive review addressing the basics of tumor immunology in relation to head and neck cancer and the cellular components potentially involved in antitumor immune responses. In addition, we describe the mechanisms by which head and neck cancer cells escape immune-mediated killing and progress to form clinically significant disease. Further, we detail what effects standard anticancer therapies may have on antitumor immune responses and how these responses may be altered by current and investigational immunotherapies. Finally, we discuss future directions that need to be considered in the development of new immunotherapeutics designed to durably alter the immune response in favor of the host.

KW - head and neck cancer

KW - immunotherapy

KW - standard therapy

KW - Tumor immunity

UR - http://www.scopus.com/inward/record.url?scp=84255191129&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84255191129&partnerID=8YFLogxK

U2 - 10.1002/lary.21913

DO - 10.1002/lary.21913

M3 - Article

C2 - 22183634

AN - SCOPUS:84255191129

VL - 122

SP - 144

EP - 157

JO - Laryngoscope

JF - Laryngoscope

SN - 0023-852X

IS - 1

ER -