TY - JOUR
T1 - The clinical features of the overlap between COPD and asthma
AU - COPDGene Investigators
AU - Hardin, Megan
AU - Silverman, Edwin K.
AU - Barr, R. Graham
AU - Hansel, Nadia N.
AU - Schroeder, Joyce D.
AU - Make, Barry J.
AU - Crapo, James D.
AU - Hersh, Craig P.
AU - Curtis, Jeffrey
AU - Kazerooni, Ella
AU - Hanania, Nicola
AU - Alapat, Philip
AU - Bandi, Venkata
AU - Guntupalli, Kalpalatha
AU - Guy, Elizabeth
AU - Mallampalli, Antara
AU - Trinh, Charles
AU - Atik, Mustafa
AU - DeMeo, Dawn
AU - Washko, George
AU - Jacobson, Francine
AU - Graham Barr, R.
AU - Thomashow, Byron
AU - Austin, John
AU - Neil MacIntyre, MacIntyre
AU - Washington, Lacey
AU - Page McAdams, H.
AU - Rosiello, Richard
AU - Bresnahan, Timothy
AU - McEvoy, Charlene
AU - Tashjian, Joseph
AU - Wise, Robert
AU - Hansel, Nadia
AU - Brown, Robert
AU - Diette, Gregory
AU - Casaburi, Richard
AU - Porszasz, Janos
AU - Fischer, Hans
AU - Budoff, Matt
AU - Sharafkhaneh, Amir
AU - Trinh, Charles
AU - Kamal, Hirani
AU - Darvishi, Roham
AU - Niewoehner, Dennis
AU - Allen, Tadashi
AU - Anderson, Quentin
AU - Rice, Kathryn
AU - Foreman, Marilyn
AU - Farzadegan, Homayoon
AU - Beaty, Terri
N1 - Publisher Copyright:
© 2011 Hardin et al; licensee BioMed Central Ltd.
PY - 2011/9/27
Y1 - 2011/9/27
N2 - Background: The coexistence of COPD and asthma is widely recognized but has not been well described. This study characterizes clinical features, spirometry, and chest CT scans of smoking subjects with both COPD and asthma. Methods: We performed a cross-sectional study comparing subjects with COPD and asthma to subjects with COPD alone in the COPDGene Study. Results: 119 (13%) of 915 subjects with COPD reported a history of physician-diagnosed asthma. These subjects were younger (61.3 vs 64.7 years old, p = 0.0001) with lower lifetime smoking intensity (43.7 vs 55.1 pack years, p = 0.0001). More African-Americans reported a history of asthma (33.6% vs 15.6%, p < 0.0001). Subjects with COPD and asthma demonstrated worse disease-related quality of life, were more likely to have had a severe COPD exacerbation in the past year, and were more likely to experience frequent exacerbations (OR 3.55 [2.19, 5.75], p < 0.0001). Subjects with COPD and asthma demonstrated greater gas-trapping on chest CT. There were no differences in spirometry or CT measurements of emphysema or airway wall thickness. Conclusion: Subjects with COPD and asthma represent a relevant clinical population, with worse health-related quality of life. They experience more frequent and severe respiratory exacerbations despite younger age and reduced lifetime smoking history. Trial registration: ClinicalTrials.gov: NCT00608764.
AB - Background: The coexistence of COPD and asthma is widely recognized but has not been well described. This study characterizes clinical features, spirometry, and chest CT scans of smoking subjects with both COPD and asthma. Methods: We performed a cross-sectional study comparing subjects with COPD and asthma to subjects with COPD alone in the COPDGene Study. Results: 119 (13%) of 915 subjects with COPD reported a history of physician-diagnosed asthma. These subjects were younger (61.3 vs 64.7 years old, p = 0.0001) with lower lifetime smoking intensity (43.7 vs 55.1 pack years, p = 0.0001). More African-Americans reported a history of asthma (33.6% vs 15.6%, p < 0.0001). Subjects with COPD and asthma demonstrated worse disease-related quality of life, were more likely to have had a severe COPD exacerbation in the past year, and were more likely to experience frequent exacerbations (OR 3.55 [2.19, 5.75], p < 0.0001). Subjects with COPD and asthma demonstrated greater gas-trapping on chest CT. There were no differences in spirometry or CT measurements of emphysema or airway wall thickness. Conclusion: Subjects with COPD and asthma represent a relevant clinical population, with worse health-related quality of life. They experience more frequent and severe respiratory exacerbations despite younger age and reduced lifetime smoking history. Trial registration: ClinicalTrials.gov: NCT00608764.
KW - Airway hyperresponsiveness
KW - Asthma
KW - Chronic obstructive pulmonary disease
KW - Emphysema
KW - Exacerbation
KW - Gas-trapping
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U2 - 10.1186/1465-9921-12-127
DO - 10.1186/1465-9921-12-127
M3 - Article
C2 - 21951550
AN - SCOPUS:80053346631
SN - 1465-9921
VL - 12
JO - Respiratory research
JF - Respiratory research
IS - 1
M1 - 127
ER -