The clinical application of targeting cancer through histone acetylation and hypomethylation

Jill Gilbert, Steve D. Gore, James G. Herman, Michael A Carducci

Research output: Contribution to journalArticle

Abstract

Methods of gene inactivation include genetic events such as mutations or deletions. Epigenetic changes, heritable traits that are mediated by changes in DNA other than nucleotide sequences, play an important role in gene expression. Two epigenetic events that have been associated with transcriptional silencing include methylation of CpG islands located in gene promoter regions of cancer cells and changes in chromatin conformation involving histone acetylation. Recent evidence demonstrates that these processes form layers of epigenetic silencing. Reversal of these epigenetic processes and up-regulation of genes important to prevent or reverse the malignant phenotype has therefore become a new therapeutic target in cancer treatment.

Original languageEnglish (US)
Pages (from-to)4589-4596
Number of pages8
JournalClinical Cancer Research
Volume10
Issue number14
DOIs
StatePublished - Jul 15 2004

Fingerprint

Acetylation
Epigenomics
Histones
Genetic Epigenesis
Neoplasms
CpG Islands
Sequence Deletion
Gene Silencing
Genetic Promoter Regions
Methylation
Genes
Chromatin
Up-Regulation
Phenotype
Gene Expression
DNA
Therapeutics

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

Cite this

The clinical application of targeting cancer through histone acetylation and hypomethylation. / Gilbert, Jill; Gore, Steve D.; Herman, James G.; Carducci, Michael A.

In: Clinical Cancer Research, Vol. 10, No. 14, 15.07.2004, p. 4589-4596.

Research output: Contribution to journalArticle

Gilbert, Jill ; Gore, Steve D. ; Herman, James G. ; Carducci, Michael A. / The clinical application of targeting cancer through histone acetylation and hypomethylation. In: Clinical Cancer Research. 2004 ; Vol. 10, No. 14. pp. 4589-4596.
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