The clinical application of proteomics

David A. Colantonio; Daniel W. Chan

doi:10.1016/j.cccn.2005.03.020

The clinical application of proteomics

David A. Colantonio, Daniel W. Chan

School of Medicine

Research output: Contribution to journal › Article › peer-review

62 Scopus citations

Abstract

Background: Proteomics is defined as a scientific approach used to elucidate all protein species within a cell or tissue, and many researchers are taking advantage of proteomic technology to elucidate protein changes between healthy and diseased states. Methods: The application of proteomic techniques and strategies to the field of medicine is slowly transforming the way biomarker discovery is conducted. However, the complexity of serum is the source of both its promise to clinical applications and its challenge to proteomic analysis. Like any new technology when it is first introduced, proteomics has been touted with much hope and promise. Results and conclusions: We provide a review of the clinical application of proteomics with the emphasis on current practical issues and challenges facing proteomic research.

Original language	English (US)
Pages (from-to)	151-158
Number of pages	8
Journal	Clinica Chimica Acta
Volume	357
Issue number	2
DOIs	https://doi.org/10.1016/j.cccn.2005.03.020
State	Published - Jul 24 2005

Keywords

Biomarkers
Clinical proteomics
Mass spectrometry
Proteomics
SELDI

ASJC Scopus subject areas

Biochemistry
Clinical Biochemistry
Biochemistry, medical

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10.1016/j.cccn.2005.03.020

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KW - SELDI

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The clinical application of proteomics

Abstract

Keywords

ASJC Scopus subject areas

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